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Genomics and functional genomics in Leishmania and Trypanosoma cruzi: statuses, challenges and perspectives

Bartholomeu, Daniella C; Teixeira, Santuza Maria Ribeiro; Cruz, Angela Kaysel.
Mem. Inst. Oswaldo Cruz; 116 (), 2021
The availability of Trypanosomatid genomic data in public databases has opened myriad experimental possibilities that have contributed to a more comprehensive understanding of the biology of these parasites and their interactions with hosts. In this review, after brief remarks on the history of the Trypa...
Biología Computacional, Genoma de Protozoos/genética, Genómica, Leishmania/genética, Trypanosoma cruzi/genética
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Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis

Ennes-Vidal, Vítor; Vitório, Bianca da Silva; Menna-Barreto, Rubem Figueiredo Sadok; Pitaluga, André Nóbrega; Gonçalves-da-Silva, Silvia Amaral; Branquinha, Marta Helena; Santos, André Luis Souza; d'Avila-Levy, Claudia Masini.
Mem. Inst. Oswaldo Cruz; 114 (), 2019
BACKGROUND Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids...
Western Blotting, Calpaína/efectos de los fármacos, Calpaína/genética, Calpaína/metabolismo, Calpaína/ultraestructura, Inhibidores de Cisteína Proteinasa/farmacología, Dipéptidos/farmacología, Citometría de Flujo, Regulación de la Expresión Génica, Genoma de Protozoos/genética, Inmunohistoquímica, Leishmania braziliensis/química, Leishmania braziliensis/genética, Leishmania braziliensis/metabolismo, Leishmania braziliensis/ultraestructura, Macrófagos Peritoneales/metabolismo, Ratones Endogámicos BALB C, Microscopía Electrónica de Transmisión, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Factores de Virulencia
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