LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Evaluation of the acute toxicity and antidiabetic activity of Coutoubea spicata “nicolau” ethanolic extract and ethyl acetate fraction

dos Santos, Jymmys Lopes; Silva, Ana Mara de Oliveira e; Souza, Lúcio Marques Vieira; Pereira, Raquel Oliveira; Lima, Clésio Andrade; Abreu, Lucas Silva; Montalvao, Monalisa Martins; Correa, Cristiane Bani; Rabelo, Thallita Kelly; Duarte, Marcelo Cavalcante; Aidar, Felipe Jose; Tavares, Josean Fechine; Estevam, Charles dos Santos; Marçal, Anderson Carlos.

Bol. latinoam. Caribe plantas med. aromát; 22 (5), 2023

In order to understand antidiabetic potential and toxicity, this study aimed to evaluate the acute toxicity and antidiabetic activity of ethanolic extract and ethyl acetate fraction obtained from Coutoubea spicata “nicolau” shoots. Chemical constituents and acute toxicity were investigated. In alloxa...

Extractos Vegetales/química, Extractos Vegetales/toxicidad, Extractos Vegetales/farmacología, Etanol, Diabetes Mellitus/tratamiento farmacológico, Gentianaceae/química, Hiperglucemia/tratamiento farmacológico, Hipoglucemiantes/química, Hipoglucemiantes/farmacología, Cromatografía Líquida de Alta Presión, Flavonoides/análisis, Fenoles/análisis, Supervivencia Celular, Ratas Wistar, Peso Corporal/efectos de los fármacos, Oxidación-Reducción/efectos de los fármacos, Hipoglucemiantes/toxicidad

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Effects of HIIT associated with Coutoubea spicata supplementation on tissue and oxidative damage biomarkers in Wistar rats

SUMMARY: This study aimed to evaluate the effects of six weeks of HIIT on tissue and oxidative damage markers in rats supplemented with Coutoubea spicata fraction. Thirty-two male Wistar rats were divided into 4 groups: Baseline (GB); supplemented with 100 mg/kg of Coutoubea spicata fraction (GSCS); exer...