LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

New candidate SNPs for genetic association with Alzheimer’s disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes

Levi-Monsalve, Alejandro; Vladimir Flores, Sergio; Manriquez, Germán; Roco-Videla, Ángel.

Medwave; 24 (1), 2024

BACKGROUND: Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer’s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association ...

Enfermedad de Alzheimer/genética, Glicoproteínas de Membrana/genética, Receptores Inmunológicos/genética, Predisposición Genética a la Enfermedad, Desequilibrio de Ligamiento, Polimorfismo de Nucleótido Simple

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Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model

Lv, Kefeng; Liu, Yuhua; Zheng, Yanbing; Dai, Shaowen; Yin, Peifeng; Miao, Haifeng.

Biol. Res; 54 (), 2021

BACKGROUNDS: Parkinson's disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PD. METHODS: SK-N-SH and SK-N-BE cells were tr...

Glicoproteínas de Membrana/genética, MicroARNs/genética, Enfermedad de Parkinson/genética, ARN Largo no Codificante/genética, Apoptosis, Proliferación Celular, Células Cultivadas

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Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/β-catenin pathway

Xu, Shuxiang; Fan, Yingying; Li, Dongping; Liu, Yan; Chen, Xu.

Braz. j. med. biol. res; 52 (1), 2019

Cervical cancer is one of the most common cancers among women around the world. However, the underlying mechanism involved in cervical cancer progression is incompletely known. In the present study, we determined the role of glycoprotein nonmetastatic melanoma protein B (GPNMB) in tumorigenesis of cervic...

Apoptosis, Western Blotting, Línea Celular Tumoral, Movimiento Celular, Proliferación Celular, Regulación Neoplásica de la Expresión Génica/genética, Metaloproteinasa 2 de la Matriz/metabolismo, Metaloproteinasa 9 de la Matriz/metabolismo, Glicoproteínas de Membrana/genética, Glicoproteínas de Membrana/metabolismo, ARN Interferente Pequeño/metabolismo, Neoplasias del Cuello Uterino/genética, Neoplasias del Cuello Uterino/metabolismo, Neoplasias del Cuello Uterino/patología, Vía de Señalización Wnt/genética, beta Catenina/genética, beta Catenina/metabolismo

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Isolation and characterization of a human cementocyte-like cell line, HCY-23

Almeida, Amanda Bandeira de; Santos, Elis Janaína Lira dos; Abuna, Gabriel Flores; Ribeiro, Cristiane Salmon; Casati, Márcio Zaffalon; Ruiz, Karina Gonzales Silvério; Nociti Júnior, Francisco Humberto.

Braz. oral res. (Online); 33 (), 2019

Abstract Cementum is the mineralized tissue covering the tooth root that functions in tooth attachment and post-eruptive adjustment of tooth position. It has been reported to be highly similar to bone in several respects but remains poorly understood in terms of development and regeneration. Here, we inv...

Proteínas Adaptadoras Transductoras de Señales, Análisis de Varianza, Proteínas Morfogenéticas Óseas/análisis, Proteínas Morfogenéticas Óseas/genética, Técnicas de Cultivo de Célula/métodos, Línea Celular, Cemento Dental/metabolismo, Proteínas de la Matriz Extracelular/análisis, Proteínas de la Matriz Extracelular/genética, Técnica del Anticuerpo Fluorescente, Expresión Génica, Marcadores Genéticos/genética, Glicoproteínas de Membrana/análisis, Glicoproteínas de Membrana/genética, Diente Molar/citología, Fosfatos/farmacología, Fosfoproteínas/análisis, Fosfoproteínas/genética, Sialoglicoproteínas/análisis, Sialoglicoproteínas/genética, Factores de Tiempo, Cemento Dental/citología

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Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population

Rani, Asima; Nawaz, Syed Kashif; Irfan, Shazia; Arshad, Muhammad; Bashir, Razia; Shaheen, Najma.

Braz. j. infect. dis; 21 (4), 2017

Abstract Introduction: The present study was designed to investigate the association between rs8177374 polymorphism and malaria symptoms due to exposure of Plasmodium vivax and Plasmodium falciparum. Materials and methods: A total of 454 samples were included in the study (228 malaria patients and 226 ...

Estudios de Casos y Controles, Frecuencia de los Genes, Predisposición Genética a la Enfermedad/genética, Genotipo, Malaria Falciparum/genética, Malaria Vivax/genética, Glicoproteínas de Membrana/genética, Glicoproteínas de Membrana/fisiología, Pakistán, Reacción en Cadena de la Polimerasa, Polimorfismo de Nucleótido Simple, Receptores de Interleucina-1/genética, Receptores de Interleucina-1/fisiología, Índice de Severidad de la Enfermedad

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Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B

Cai, Guilan; Qiao, Shanshan; Chen, Kui.

Biol. Res; 48 (), 2015

BACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA (miR)...

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Suppression of miR-181 a attenuates H2O2-induced death of mesenchymal stem cells by maintaining hexokinase II expression

Lee, Seahyoung; Yun, Ina; Ham, Onju; Lee, Se-Yeon; Lee, Chang Yeon; Park, Jun-Hee; Lee, Jiyun; Seo, Hyang-Hee; Choi, Eunhyun; Hwang, Ki-Chul.

Biol. Res; 48 (), 2015

BACKGROUND: Low survival rate of transplanted cells compromises the efficacy of cell therapy. Hexokinase II (HKII) is known to have anti-apoptotic activity through its interaction with mitochondria. The objective was to identify miRNAs targeting HKII and investigate whether miRNA-mediated modulation of H...

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