LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Macrophage migration inhibitory factor antagonist (p425) ameliorates kidney histopathological and functional changes in diabetic rats

Khalilpour, Jamal; Roshan-Milani, Shiva; Gharalari, Farzaneh Hosseini; Fard, Amin Abdollahzade.

J. bras. nefrol; 41 (3), 2019

Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eight...

Albuminuria/tratamiento farmacológico, Glucemia, Creatinina/sangre, Creatinina/orina, Diabetes Mellitus Experimental/sangre, Diabetes Mellitus Experimental/inducido químicamente, Diabetes Mellitus Experimental/patología, Diabetes Mellitus Experimental/orina, Nefropatías Diabéticas/sangre, Nefropatías Diabéticas/terapia, Nefropatías Diabéticas/patología, Nefropatías Diabéticas/orina, Modelos Animales de Enfermedad, Glicosaminoglicanos/orina, Oxidorreductasas Intramoleculares/antagonistas & inhibidores, Riñón/patología, Activación de Macrófagos, Factores Inhibidores de la Migración de Macrófagos/antagonistas & inhibidores, Sustancias Protectoras/farmacología, Sustancias Protectoras/uso terapéutico, Ratas Wistar, Estreptozocina/farmacología

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Do comportamento dos glicosaminoglicanos urinários em pacientes portadores de neoplasias da cabeça e pescoço: estudo preliminar

Behavior of urinary glycosaminoglycans in head and neck neoplasms patients: preliminary study

Os glicosaminoglicanos excretados na urina foram estudados por DIETRICH e col (1993) por meio de eletroforese em gel, degradaçao enzimática e cromatografia, em indivíduos adultos sadios e em portadores de neoplasias diversas. Os autores demonstraram que esses compostos, em especial o condroitim sulfat...