Abstract Brain tumors are one of the most common causes of cancer-related deaths around the world. Angiogenesis is critical in high-grade malignant gliomas, such as glioblastoma multiforme. Objective: The aim of this study is to comparatively analyze the angiogenesis-related genes, namely VEGFA, VEGFB,...
Neoplasias Encefálicas/genética,
Carcinogénesis/genética,
Expresión Génica,
Glioblastoma/genética,
Glioblastoma/patología,
Glioma/genética,
Glioma/patología,
Interleucina-8/análisis,
Neovascularización Patológica/genética,
Mutación Puntual/genética,
Receptores de Interleucina-8A/análisis,
Receptores de Interleucina-8B/análisis,
Valores de Referencia,
Factor A de Crecimiento Endotelial Vascular/análisis,
Factor B de Crecimiento Endotelial Vascular/análisis,
Receptor 2 de Factores de Crecimiento Endotelial Vascular/análisis
Introduction: Gliomas are neoplasms with high recurrence and mortality. Due to the difficulty to apply the World Health Organization (2016) classification, developing countries continue to use histological evaluation to diagnose and classify these neoplasms. Objective: To develop a semi-quantitative sca...
Astrocitoma/mortalidad,
Astrocitoma/patología,
Neoplasias Encefálicas/clasificación,
Neoplasias Encefálicas/mortalidad,
Neoplasias Encefálicas/patología,
Estudios de Cohortes,
Ependimoma/mortalidad,
Ependimoma/patología,
Glioblastoma/mortalidad,
Glioblastoma/patología,
Glioma/clasificación,
Glioma/patología,
Clasificación del Tumor,
Oligodendroglioma/mortalidad,
Oligodendroglioma/patología,
Análisis de Supervivencia
SUMMARY Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. She was in amenorrhea. ...
Biopsia,
Neoplasias Encefálicas/diagnóstico por imagen,
Neoplasias Encefálicas/patología,
Neoplasias Encefálicas/cirugía,
Resultado Fatal,
Glioma/diagnóstico por imagen,
Glioma/patología,
Glioma/cirugía,
Imagen por Resonancia Magnética,
Silla Turca,
Tercer Ventrículo/diagnóstico por imagen,
Tercer Ventrículo/patología,
Tercer Ventrículo/cirugía,
Resultado del Tratamiento
Calastri, Maria Clara Jessica;
Rodrigues, Nicolas Luz Toledo Ortega;
Hatori, Gabriela;
Gregório, Michele Lima;
Brancati, Camila Ive Ferreira Oliveira;
Zanovelo, Eliane Milharcix;
Ferraz Filho, José Roberto Lopes;
Neiva, Cassiano Merussi;
Rodrigues Junior, Antonio Carlos Ponde;
Godoy, Moacir Fernandes de;
Lancelloti, Carmen Lucia Penteado;
Tognola, Waldir Antonio;
Souza, Dorotéia Rossi Silva.
ABSTRACT Background Glioma, the most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. The objectives of this study were to evaluate the association of genetic polymorphisms related to angiogenesis and apoptosis with gliomas, as well as comorbidi...
Antineoplásicos Alquilantes/administración & dosificación,
Apoptosis/genética,
Neoplasias Encefálicas/genética,
Neoplasias Encefálicas/patología,
Neoplasias Encefálicas/terapia,
Terapia Combinada,
Dacarbazina/administración & dosificación,
Dacarbazina/análogos & derivados,
Genotipo,
Glioma/genética,
Glioma/patología,
Glioma/terapia,
Estimación de Kaplan-Meier,
Estilo de Vida,
Neovascularización Patológica,
Polimorfismo Genético/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Temozolomida
Development of neuroimaging in the last decades has revolutionized the neurological diagnosis, however for they interpretation clinical picture of the patient remains as a relevant aspect. Clinical case: a 30-year-old male patient with recent epileptic seizures, Jaksonian type, secondarily generalized, w...
Solution reflux and edema hamper the convection-enhanced delivery of the standard treatment for glioma. Therefore, a real-time magnetic resonance imaging (MRI) method was developed to monitor the dosing process, but a quantitative analysis of local diffusion and clearance parameters has not been assessed...
Western Blotting,
Neoplasias Encefálicas/diagnóstico por imagen,
Neoplasias Encefálicas/patología,
Difusión,
Progresión de la Enfermedad,
Espacio Extracelular/diagnóstico por imagen,
Gadolinio DTPA,
Glioma/diagnóstico por imagen,
Glioma/patología,
Inmunohistoquímica,
Imagen por Resonancia Magnética/métodos,
Ratas Sprague-Dawley
ABSTRACT Gliomas account for the majority of primary malignant brain tumors and present invasive behavior into adjacent healthy tissue. While 4-NC had previously shown to induce apoptotic cell death in a melanoma model, for the glioma model described in this paper 4-NC is cytotoxic for the cells with the...
BACKGROUND: MiR-320 is downregulated in multiple cancers, including glioma and acts as tumor suppressor through inhibiting tumor cells proliferation and inducing apoptosis. PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been reported to be upregulated in various tumors and ...
Neoplasias Encefálicas/metabolismo,
Glioma/metabolismo,
Proteínas de Homeodominio/metabolismo,
MicroARNs/metabolismo,
Proteínas Proto-Oncogénicas/metabolismo,
Neoplasias Encefálicas/patología,
Diferenciación Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Glioma/patología,
Línea Celular Tumoral,
Regulación hacia Abajo,
Regulación Neoplásica de la Expresión Génica,
Regulación hacia Arriba
BACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA (miR)...
Apoptosis,
Neoplasias Encefálicas/patología,
Proliferación Celular,
Glioma/patología,
Glicoproteínas de Membrana/farmacología,
MicroARNs/antagonistas & inhibidores,
Semaforinas/farmacología,
Neoplasias Encefálicas/metabolismo,
Glioma/metabolismo,
Luciferasas/metabolismo,
Glicoproteínas de Membrana/genética,
MicroARNs/metabolismo,
Semaforinas/genética,
Western Blotting,
Línea Celular Tumoral,
Movimiento Celular,
Regulación Neoplásica de la Expresión Génica,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal
