LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Propentofylline decreases hypothalamic astrogliosis induced by hypercaloric diet in the rat

Bondan, Eduardo Fernandes; Vieira, Carolina Cardoso; Martins, Maria de Fátima Monteiro; Kirsten, Thiago Berti; Bernardi, Maria Martha.

Arq. neuropsiquiatr; 76 (4), 2018

ABSTRACT Obesity is associated with a chronic and low-grade inflammatory response in the hypothalamus, where astrogliosis occurs with the upregulation of the astrocyte structural protein GFAP. As propentofylline (PPF) has inhibitory effects on astrocyte and microglial activation during inflammation, this...

Dieta Alta en Grasa/efectos adversos, Proteína Ácida Fibrilar de la Glía/análisis, Gliosis/etiología, Gliosis/prevención & control, Enfermedades Hipotalámicas/etiología, Enfermedades Hipotalámicas/prevención & control, Ratas Wistar, Xantinas/administración & dosificación

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Glial scar-modulation as therapeutic tool in spinal cord injury in animal models

Abstract Purpose: Spinal Cord injury represents, in veterinary medicine, most of the neurological attendances and may result in permanent disability, death or euthanasia. Due to inflammation resulting from trauma, it originates the glial scar, which is a cell interaction complex system. Its function is...