Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2α mediated changes in the expression of occludin and ZO-1
Braz. j. med. biol. res; 51 (7), 2018
This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The expression level of HIF-2α and tight junction proteins (occl...
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo, Hipoxia de la Célula/fisiología, Proliferación Celular, Células Endoteliales/química, Células Endoteliales/metabolismo, Glomérulos Renales/citología, Ocludina/metabolismo, Permeabilidad, Factores de Tiempo, Proteína de la Zonula Occludens-1/metabolismo