LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy

Wanderley, David Campos; Jones, Bárbara Dornelas; Barbosa, Fabricio Augusto Marques; Araujo, Stanley de Almeida.

J. bras. nefrol; 42 (2), 2020

ABSTRACT Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of autoantibodies (PLA2R and THSD7A) directe...

Biopsia, Glomerulonefritis Membranosa/diagnóstico, Glomerulonefritis Membranosa/etiología, Glomerulonefritis Membranosa/inmunología, Glomerulonefritis Membranosa/patología, Glomérulos Renales/patología, Receptores de Fosfolipasa A2/inmunología, Trombospondinas/inmunología

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Complement System and C4d expression in cases of Membranous nephropathy

Abstract Introduction: Membranous nephropathy (MN) is one of the major causes of nephrotic syndrome. The complement system plays a key role in the pathophysiology of MN. Objectives: To identify the complement pathway possibly activated in MN cases and correlate the presence of C4d with more severe clin...