LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The Role of Histone Deacetylase Inhibitors in Regulation of Akt/GSK-3β Signaling Pathway in Mice Following Transient Focal Cerebral Ischemia

Zhao, Bo; Liu, Lian; Leng, Yan; Yuan, Quan; Hou, Jiabao; Wu, Yang; Gao, Wenwei.

Acta cir. bras; 32 (10), 2017

Abstract Purpose: To investigate whether the neuroprotective effect of TSA on cerebral ischemia reperfusion injury is mediated by the activation of Akt/GSK-3β signaling pathway. Methods: Mice were randomly divided into four groups (n=15): sham group (S); ischemia reperfusion group (IR); ischemia...

Modelos Animales de Enfermedad, Glucógeno Sintasa Quinasa 3/efectos de los fármacos, Glucógeno Sintasa Quinasa 3/metabolismo, Inhibidores de Histona Desacetilasas/farmacología, Ataque Isquémico Transitorio/metabolismo, Ataque Isquémico Transitorio/fisiopatología, Ratones Endogámicos BALB C, Fármacos Neuroprotectores/farmacología, Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos, Transducción de Señal/efectos de los fármacos, Transducción de Señal/fisiología

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Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway

BACKGROUND: The fetus is surrounded by the amniotic fluid (AF) contained by the amniotic sac of the pregnant female. The AF is directly conveyed to the fetus during pregnancy. Although AF has recently been reported as an untapped resource containing various substances, it remains unclear whether the AF c...