Molecular changes that affect mitochondrial glycolysis have been associated with the maintenance of tumor cells. Some metabolic factors have already been described as predictors of disease severity and outcomes. This systematic review was conducted to answer the question: Is the glycolytic pathway correl...
Wunderlich, A L M;
Azevedo, S C S F;
Yamada, L A;
Bataglini, C;
Previate, C;
Campanholi, K S S;
Pereira, P C S;
Caetano, W;
Kaplum, V;
Nakamura, C V;
Nakanishi, A B S;
Comar, J F;
Pedrosa, M M D;
Godoi, V A F.
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditio...
Clorofila/administración & dosificación,
Clorofila/análogos & derivados,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Quimioterapia Combinada,
Metabolismo Energético/efectos de los fármacos,
Glucólisis/efectos de los fármacos,
Glucólisis/fisiología,
Hígado/patología,
Hígado/fisiopatología,
Estrés Oxidativo/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Fotoquimioterapia,
Fármacos Fotosensibilizantes/administración & dosificación,
Ratas Wistar
The development of chemotherapy resistance significantly impairs the efficiency of chemotherapy, but the underlying mechanisms of chemotherapy resistance in gastric cancer (GC) are complicated and still need to be further explored. Here, we aimed to reveal the effects of miR-4290/PDK1 (pyruvate dehydroge...
Apoptosis/efectos de los fármacos,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Cisplatino/farmacología,
Resistencia a Antineoplásicos/genética,
Citometría de Flujo,
Regulación Neoplásica de la Expresión Génica,
Glucólisis/genética,
MicroARNs/metabolismo,
Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/genética,
Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Neoplasias Gástricas/metabolismo,
Transfección
Aim: The present study aimed to verify if there is a difference between genders in anaerobic capacity
estimated by energetic equivalents of glycolytic and phosphagen pathways (AC[La-]+EPOCfast). Methods: In this way, 8
men and 8 women (physical education students) were subjected to the following sequence...
Background: Lactate dehydrogenase (LDH) is an enzyme of glycolytic pathway, ubiquitously found in living organisms. Increased glycolysis and LDH activity are associated with many pathologic conditions including inflammation and cancer, thereby making the enzyme a suitable drug target. Studies on conserve...
Background: The production of recombinant proteins for therapeutic use represents a great impact on the biotechnology industry. In this context, established mammalian cell lines, especially CHO cells, have become a standard system for the production of such proteins. Their ability to properly configure a...
CONTEXT: The preservative solution ADSOL (adenine, dextrose, sorbitol, sodium chloride and mannitol) maintains red cell viability for blood trans-fusion for 6 weeks. It would be useful to know about its preservation qualities over longer periods. OBJECTIVE: To determine some red cell biochemical paramete...
Membrana Eritrocítica/enzimología,
Conservación de la Sangre,
Adenina,
Glucosa,
Proteínas de la Membrana/análisis,
Manitol,
Cloruro de Sodio,
Membrana Eritrocítica/química,
2,3-Difosfoglicerato/análisis,
Electroforesis en Gel de Poliacrilamida,
Glucólisis,
Concentración de Iones de Hidrógeno,
Adenosina Trifosfato/análisis,
Oxidorreductasas/análisis
La designación como ponente de la XVIII Conferencia Annual "Karl Gaede", instituída por la Asociación Venezolana de Bioquímica y Biología Molecular, me brindó la oportunidad para emprender un viaje retrospectivo a través de algunos aspectos de la actividad de investigación realizada a lo largo de...
