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Beneficial role of oleuropein in sepsis-induced myocardial injury. Possible Involvement of GSK-3β/NF-kB pathway

Xing, Conghui; Xu, Li; Yao, Yingjie.
Acta cir. bras; 36 (1), 2021
ABSTRACT Purpose The present study explored the potential therapeutic role of oleuropein in sepsis-induced heart injury along with the role of GSK-3β/NF-kB signaling pathway. Methods Sepsis-induced myocardial injury was induced by cecal ligation and puncture (CLP) in rats. The cardiac injury was a...
Glucógeno Sintasa Quinasa 3 beta, Lesiones Cardíacas/tratamiento farmacológico, Glucósidos Iridoides, Iridoides, FN-kappa B, Sepsis/complicaciones, Sepsis/tratamiento farmacológico
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Picroside II attenuates ischemia/reperfusion testicular injury by alleviating oxidative stress and apoptosis through reducing nitric oxide synthesis

Li, Yanze; Wang, Lei; Chen, Zhiyuan; Liu, Xiuheng.
Acta cir. bras; 34 (11), 2019
Abstract Purpose: To investigate the effect of Picroside II on testicular ischemia and reperfusion (l/R) injury and the underlying mechanism. Methods: Sprague-Dawley rats were randomly divided into 4 groups: sham operated group (Sham), Sham with Picroside II treatment group (Sham+ Pic II), l/R group (l...
Apoptosis/efectos de los fármacos, Western Blotting, Cinamatos/farmacología, Hemo-Oxigenasa 1/análisis, Etiquetado Corte-Fin in Situ, Glucósidos Iridoides/farmacología, Malondialdehído/análisis, NADP/análisis, Óxido Nítrico/biosíntesis, Estrés Oxidativo/efectos de los fármacos, Peroxidasa/análisis, Distribución Aleatoria, Ratas Sprague-Dawley, Daño por Reperfusión/metabolismo, Daño por Reperfusión/patología, Daño por Reperfusión/prevención & control, Testículo/irrigación sanguínea
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