LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effect of Brassica rapa var. rapifera on Insulin Resistance and Inflammatory Analysis of Visceral Adipose Tissue of Obese Wistar Rats Under Glucolipotoxicity Condition

Smail, Leila; Hamlat, Nadjiba; Berdja, Sihem; Boumaza, Saliha; Neggazi, Samia; Kacimi, Ghouti; Boudarene, Lynda; Bouguerra, Souhila Aouichat.

Int. j. morphol; 42 (1), 2024

SUMMARY: Obesity-related pathophysiologies such as insulin resistance and the metabolic syndrome show a markedly increased risk for type 2 diabetes and atherosclerotic cardiovascular disease. This risk appears to be linked to alterations in adipose tissue function, leading to chronic inflammation and the...

Brassica rapa/química, Extractos Vegetales/administración & dosificación, Extractos Vegetales/uso terapéutico, Resistencia a la Insulina, Tejido Adiposo/efectos de los fármacos, Grasa Intraabdominal, Inflamación, Ratas Wistar, Obesidad/tratamiento farmacológico, Diabetes Mellitus Tipo 2/tratamiento farmacológico, Glucosa/toxicidad, Lípidos/toxicidad

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Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

BACKGROUND: Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target. METHODS: HT22 cells were cultured in 25 or 50 mM ...