SUMMARY: Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, testosterone inhibition and apoptosis. Accordingly, this study was co...
Camellia sinensis/química,
Extractos Vegetales/farmacología,
Té/química,
Infliximab/farmacología,
Cisplatino/toxicidad,
Testículo/efectos de los fármacos,
Recuento de Espermatozoides,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
Apoptosis,
Estrés Oxidativo,
Inflamación,
Ratas Sprague-Dawley,
Extractos Vegetales/química,
Inmunohistoquímica,
Malondialdehído/análisis,
Glutatión/análisis,
Testículo/patología
Introducción: Las alteraciones en el estado redox celular se han descrito como factores causales en diversas enfermedades. La depleción del glutatión reducido se ha asociado fundamentalmente a enfermedades neurodegenerativas, pulmonares, hepáticas, cardiovasculares e inmunológicas. Objetivo: Dete...
Cardiovascular disease(CVD) remains the major cause of mortality in the world, typically claiming a third of all deaths. The primary cause of CVD is atherosclerosis. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manif...
Aterosclerosis/dietoterapia,
Dieta Aterogénica/métodos,
Aceite de Oliva/farmacología,
Colesterol/farmacología,
Dieta Alta en Grasa/métodos,
Estrés Oxidativo/inmunología,
Glutatión/farmacología,
Peroxidación de Lípido/inmunología,
Triglicéridos/farmacología,
Hipercolesterolemia/inmunología,
Lipoproteínas/inmunología,
Ratas Wistar/inmunología
Abstract Liver ischemia-reperfusion (IR) injury is a major clinical trouble encountered in clinical practice. This study aimed to examine the therapeutic effects of silymarin (SM) plus glutathione (GSH) on hepatic IR injury using a rat model of liver IR. Fifty male rats were randomly divided into five gr...
In this study, against streptozotocin (STZ) induced diapetic nephropathy (DN); it is aimed to investigate the use of thymoquinone (TQ) and β-aminoisobutyric acid (BAIBA) and to compare the effects of these agents. With random selection of 35 male rats, five groups (seven rats in each group) were consti...
Benzoquinonas/administración & dosificación,
Ácidos Aminoisobutíricos/administración & dosificación,
Nefropatías Diabéticas/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Estreptozocina,
Ratas Sprague-Dawley,
Inmunohistoquímica,
Estrés Oxidativo,
Riñón/efectos de los fármacos,
Peso Corporal,
Glucosa/análisis,
Glutatión/análisis,
Nitrógeno de la Urea Sanguínea,
Creatinina/análisis
The objective of this study was to evaluate the rate of conception, metabolic, and structural conditions of cryopreserved bovine sperm cells, plus extender with IGF-1 and glutathione (GSH). 12 ejaculations of Nelore bulls were used, submitted to treatments: control, gSH (2mM/mL), IGF-1 (100ng/mL) and gSH...
Objective: In this work, rats isolated hearts were infused EPA before the ischemia period and during reperfusion for available get well in parameter
relatives to redox reactions. Methods: The effect of EPA was tested on isolated hearts induced to ischemia and reperfusion, treatment occurred at different
...
Abstract Introduction Due to its ability to arrest untreated dental caries, silver diamine fluoride (SDF) has been advocated for indirect pulp capping procedures. However, the high concentrations of silver and fluoride in SDF raise concerns about its biocompatibility to pulpal tissues. Objectives Thi...
This study aimed to evaluate the addition of Vitamin C, reduced Glutathione and trolox on sperm characteristics of pork refrigerated semen. Six pigs were collected through the technique of gloved hand (10 ejaculates/animals). The semen was diluted in MR-A®. After the previous evaluations, the treatments...
The aim of this study was to evaluate the addition of vitamin C, reduced glutathione and the association thereof to the bovine semen cryopreservation extender. The ejaculate from nine bulls were divided into four fractions, each corresponding to a treatment, namely: control group-semen diluted with Tris-...
