Nódulo necrótico solitario: un hallazgo inesperado. A propósito de un caso
Rev. argent. radiol; 87 (1), 2023
Results: 14
Study on the effect of processing methods on the total polyphenol, 2,3,5,4’-tetrahydroxystilben-2-O-β-D-glucoside, and physcion contents in Fallopia multiflora Thunb. Haraldson root
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract This study investigated the changes in the ingredients in Fallopia multiflora Thunb. Haraldson (FMT) root after processing it with different methods such as soaking, stewing, and steaming or combined methods. The total polyphenol, 2,3,5,4′-tetrahydroxystilben-2-O-β-D-glucoside (THSG), and ph...
The Human Host Defense Peptide LL-37 Overexpressed in Lung Cell Lines by Methanolic Extract of Valeriana officinalis
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract The present study investigated the effects of valerian methanolic extract and valerenic acid on the expression of LL-37 gene and protein in A549 and MRC5 line cells. After preparing Valerian seeds, sowing them in March 2020, and harvesting the rhizome in October 2020, the extract was prepared fr...
Valeriana/efectos adversos, Extractos Vegetales/efectos adversos, Catelicidinas/efectos adversos, Genes/genética, Cromatografía Líquida de Alta Presión/métodos, ddcs0244440, Células A549/clasificación, Hígado/anomalías, Péptidos Catiónicos Antimicrobianos/agonistas, d0024700, Western Blotting/instrumentación
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: A randomized clinical trial
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Hepatoprotective effects of many herbal agents have been reported in animal studies and clinical trials. In this study, five hepatoprotective plants with potent antioxidant, anti-inflammatory, and hypolipidemic effects were chosen to prepare a polyherbal compound for managing NAFLD. Sixty patien...
Plantas Medicinales/metabolismo, Cynara scolymus/metabolismo, Citrus/metabolismo, Anethum graveolens/metabolismo, Alanina Transaminasa/efectos adversos, Antioxidantes/clasificación, Colesterol/farmacología, Cápsulas, Dieta Saludable/instrumentación, Hígado/anomalías, Enfermedad del Hígado Graso no Alcohólico, Pacientes
Free interstitial levels of metformin in the liver of healthy and diabetic Wistar rats
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract In the present study, free interstitial levels reached by metformin in the liver were investigated in control and diabetic rats by microdialysis. Firstly, a bioanalytical method using an HPLC-UV system to determine the drug concentration in microdialysis samples was validated. The blood glucose ...
Protective effects of Baicalin injection on severe acute pancreatitis through regulating follistatin-like-1 signaling pathway by down-regulating miR-429 expression in mice
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract In China, Scutellaria is used for treating inflammatory-related diseases. Baicalin is the main active component of Scutellaria and has protective effects on acute pancreatitis. However, the mechanism of Baicalin is still unclear. In this study, the protective effects of baicalin on acute pancrea...
Effects of low-level laser therapy on liver regeneration and laser parameters employed
Arq. ciências saúde UNIPAR; 25 (3), 2021
Low-level laser therapy has several biological effects; one of them is tissue regeneration. Recent studies have been held on the application of laser therapy on the liver of rats after partial hepatectomy to promote liver regeneration. The aim of this article was to review the recent studies on the effec...
Effect of long-term consumption of oxidized polyunsaturated fatty acids on atherosclerotic lesion in LDL receptor knockout mice
Polyunsaturated fatty acids (PUFA) are susceptible to enzymatic and non-enzymatic oxidation, leading to the production of secondary compounds that present different physiological effects. Among the PUFA, the products formed from Omega 6 (n-6 FA) and Omega 3 (n-3 FA) fatty acids oxidation can modulate inf...
Palbociclib in breast cancer neoadjuvant setting
Autops. Case Rep; 11 (), 2021
Cyclin-dependent kinase 4/6 inhibitors represent a major advance in breast cancer treatment, emerging as the standard of care of the initial treatment of hormone receptor-positive and HER2-negative metastatic breast cancer. Their activity in this subset of patients leads to interest in their use in the a...
Effects of treatment with sitagliptin on hepatotoxicity induced by acetaminophen in mice
Braz. J. Pharm. Sci. (Online); 56 (), 2020
Up to date, the management of hepatotoxicity induced by a suicidal or unintentional overdose of acetaminophen (APAP) remains a therapeutic challenge. The present study aimed to elucidate the potential effect of sitagliptin, a DPP-4 inhibitor, to ameliorate the acute injurious effects of acetaminophen on ...