LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice

Lange, A P; Almeida, L Y; Araújo Silva, C L; Scheucher, P S; Chahud, F; Krause, A; Bohlander, S K; Rego, E M.

Braz. j. med. biol. res; 52 (6), 2019

Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T...

Enfermedad Aguda, Proteína alfa Potenciadora de Unión a CCAAT/genética, Citometría de Flujo, Genotipo, Haploinsuficiencia/genética, Hematopoyesis/genética, Leucemia Mieloide Aguda/genética, Ratones Transgénicos, Fenotipo, Factores de Transcripción/genética, Translocación Genética/genética

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