Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms
Braz. j. med. biol. res; 50 (12), 2017
The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hem...
Apoptosis/efectos de los fármacos, Movimiento Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Hemangioma/tratamiento farmacológico, Hemangioma/metabolismo, Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo, Propranolol/uso terapéutico, Vasodilatadores/uso terapéutico