The neuroprotection of cerebrolysin after spontaneous intracerebral hemorrhage through regulates necroptosis via Akt/ GSK3B signaling pathway
Acta cir. bras; 36 (10), 2021
ABSTRACT Purpose: Spontaneous intracerebral hemorrhage (ICH) is a major cause of death and disability with a huge economic burden worldwide. Cerebrolysin (CBL) has been previously used as a nootropic drug. Necroptosis is a programmed cell death mechanism that plays a vital role in neuronal cell death af...
Aminoácidos, Apoptosis, Hemorragia Cerebral/tratamiento farmacológico, Glucógeno Sintasa Quinasa 3 beta/farmacología, Ratones Endogámicos C57BL, Necroptosis, Neuronas/metabolismo, Neuroprotección, Fármacos Neuroprotectores/farmacología, Proteínas Proto-Oncogénicas c-akt/metabolismo, Transducción de Señal