Abstract INTRODUCTION: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study ...
Alelos,
Antígenos de Plaqueta Humana/sangre,
Antígenos de Plaqueta Humana/genética,
Genotipo,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/complicaciones,
Persona de Mediana Edad,
Polimorfismo Genético/genética,
Enfermedades Reumáticas/sangre,
Enfermedades Reumáticas/etiología,
Factores de Riesgo
Abstract INTRODUCTION: The present study investigated the association of the rs2794521 polymorphism in the CRP gene in individuals with chronic hepatitis B and C, correlating it with markers of hepatic inflammation, fibrosis scores, viral load, and plasma protein levels. METHODS: The study analyzed 185...
Biomarcadores/sangre,
Proteína C-Reactiva/análisis,
Proteína C-Reactiva/genética,
Estudios de Casos y Controles,
Estudios Transversales,
Genotipo,
Hepatitis B Crónica/sangre,
Hepatitis B Crónica/genética,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/genética,
Cirrosis Hepática/sangre,
Cirrosis Hepática/virología,
Índice de Severidad de la Enfermedad,
Carga Viral
Abstract INTRODUCTION: IgG subclasses involved in the immune response to hepatitis C virus (HCV) antigens have been rarely studied. We investigated the immune response mediated by IgG1 and IgG4 antibodies against the recombinant core and NS3 antigens in patients with chronic hepatitis C. METHODS: Six...
Alanina Transaminasa/sangre,
Estudios de Casos y Controles,
Crioglobulinemia,
Ensayo de Inmunoadsorción Enzimática,
Hepacivirus/inmunología,
Anticuerpos contra la Hepatitis C/sangre,
Anticuerpos contra la Hepatitis C/inmunología,
Antígenos de la Hepatitis C/sangre,
Antígenos de la Hepatitis C/inmunología,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/inmunología,
Inmunoglobulina G/sangre,
Cirrosis Hepática/virología,
Persona de Mediana Edad,
Valores de Referencia,
Estadísticas no Paramétricas,
Carga Viral,
Viremia
Abstract INTRODUCTION: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytoki...
Antivirales/administración & dosificación,
Citocinas/sangre,
Quimioterapia Combinada,
Citometría de Flujo,
Genotipo,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/tratamiento farmacológico,
Persona de Mediana Edad,
Oligopéptidos/administración & dosificación,
Prolina/administración & dosificación,
Prolina/análogos & derivados,
Estudios Prospectivos,
Resultado del Tratamiento,
Carga Viral
Background. Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. Aim: To evaluate the impact of IFNL4 rs12...
Hepatitis C Crónica/genética,
Interleucinas/genética,
Cirrosis Hepática/genética,
Antivirales/uso terapéutico,
Chile,
Genotipo,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/tratamiento farmacológico,
Interferones/uso terapéutico,
Cirrosis Hepática/sangre,
Polimorfismo de Nucleótido Simple,
Estudios Retrospectivos,
Factores de Riesgo
Summary Objective: Chronic hepatitis C (CHC) continues to be a critical problem. The liver fibrosis score is the most valuable tool in determining treatment and prognosis. Liver biopsy is still considered a gold method but, due to unmet needs, new non-invasive markers are required. The aim of this study...
ABSTRACT Objective: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. Subjects and methods: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janei...
ABSTRACT BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and t...
Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to det...
Plaquetas/química,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/complicaciones,
Cirrosis Hepática/sangre,
Cirrosis Hepática/virología,
Persona de Mediana Edad,
Factor de Crecimiento Derivado de Plaquetas/análisis,
Reacción en Cadena de la Polimerasa,
Proteínas Proto-Oncogénicas c-sis/sangre,
ARN Mensajero/análisis,
Índice de Severidad de la Enfermedad,
Factor de Crecimiento Transformador beta1/sangre
Objetivos: Avaliar a relação entre parâmetros laboratoriais e o grau de fibrose e atividade
inflamatória na biópsia hepática. Metodologia: Estudo transversal de análise de dados
laboratoriais e histopatológicos obtidos de forma consecutiva em 210 pacientes com
infecção por VHC que foram submeti...
