Purpose: This study evaluated the protective effect of hesperidin on injury induced by gastric ischemia-reperfusion. Methods: Fifty male Sprague Dawley rats (250–300 g) were divided into five groups: control (C), sham (S), ischemia (I), ischemia-reperfusion (I/R) and hesperidin + ischemia-reperfusion (...
Purpose: The effects of hesperidin application on the wound caused by esophageal burns were investigated in this study. Methods: Wistar albino rats were divided into three groups: Control group: only 1 mL of 0.09% NaCl was administered i.p. for 28 days; Burn group: An alkaline esophageal burn model was c...
Abstract Hesperidin is a natural compound which is found in citric fruits and presents antitumor and antimicrobial activities. However, the in vivo efficacy of Hesperidin is reduced due to its low oral bioavailability. Protein-based nanoparticles have been applied to improve biological parameters of drug...
Las infecciones respiratorias constituyen una importante causa de morbilidad y mortalidad a nivel mundial, incrementándose su relevancia ante la reciente infección por SARS-CoV-2, causante de la pandemia de COVID-19. Las opciones terapéuticas para esta infección respiratoria son escasas y sin eficaci...
Plantas Medicinales/efectos de los fármacos,
COVID-19,
Infecciones del Sistema Respiratorio,
Betacoronavirus,
Ajo,
Aloe,
Catequina/uso terapéutico,
Curcumina/uso terapéutico,
Echinacea,
Diosmina,
Eucalyptus,
Hesperidina,
Psidium,
Salvia officinalis,
Terapéutica,
Guatemala
As laranjas e seus derivados, principalmente os sucos, possuem compostos bioativos, tais como os flavonoides, entre eles as flavanonas hesperidina e narirutina, que podem estar relacionados à promoção e benefícios à saúde. A absorção e metabolização de flavonoides podem ser afetadas por diverso...
Hesperidin, a natural compound, suppresses the epithelial-to-mesenchymal transition through the TGF-β1/Smad signaling pathway. However, studies on the detailed effects and mechanisms of hesperidin are rare. The present study showed that, for A549 alveolar epithelial cells, the anti-proliferative effects...
ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdomin...
Acetilcisteína/farmacología,
Acetilcisteína/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Lesión Renal Aguda/prevención & control,
Antioxidantes/farmacología,
Antioxidantes/uso terapéutico,
Brasil,
Ciego/efectos de los fármacos,
Ciego/lesiones,
Diosmina/farmacología,
Diosmina/uso terapéutico,
Modelos Animales de Enfermedad,
Hesperidina/farmacología,
Hesperidina/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Sepsis/complicaciones,
Sepsis/tratamiento farmacológico
RESUMO Objetivo Avaliar ação renoprotetora dos flavonoides diosmina e hesperidina na prevenção da nefrotoxicidade da anfotericina B em modelo experimental com ratos. Método Ratos Wistar, adultos, machos foram distribuídos nos seguintes grupos: Salina; diosmina hesperidina (animais receberam 50 mg/k...
