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Simultaneous determination of candesartan and hydrochlorothiazide in human plasma by LC-MS/MS

Bonthu, Mohan Gandhi; Atmakuri, Lakshmana Rao; Jangala, Venkateswara Rao.
Braz. J. Pharm. Sci. (Online); 54 (1), 2018
Abstract A simple, sensitive, rapid and highly efficient LC-MS/MS method was developed for the determination of Candesartan and Hydrochlorothiazide simultaneously in human plasma. The method employed Zorbax eclipse C18 (150 X 4.6 mm, 5µ) column using acetate buffer: acetonitrile (25:75%, v/v) as the mob...
Hidroclorotiazida/análisis, Cromatografía Liquida/métodos, Espectrometría de Masas/métodos, Plasma, Estudio de Validación
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Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions

Ghaderi, Faranak; Nemati, Mahboob; Siahi-Shadbad, Mohammad Reza; Valizadeh, Hadi; Monajjemzadeh, Farnaz.
Braz. j. pharm. sci; 52 (4), 2016
ABSTRACT The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated in pharmaceutical formulations. In this study, the activation energy of - hydrohlorothiazide and lactose interaction in the liquid state was ascertained under basic and neutral conditions. Convention...
Cromatografía Líquida de Alta Presión/métodos, Hidroclorotiazida/análisis, Reacción de Maillard, Lactosa/análisis, Cinética, Preparaciones Farmacéuticas/clasificación
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Bioanalytical method development and validation for determination of metoprolol tartarate and hydrochlorothiazide using HPTLC in human plasma

Rote, Ambadas Ranganath; Sonavane, Poonam Ramdas.
Braz. j. pharm. sci; 49 (4), 2013
A simple, sensitive, rapid and economic chromatographic method has been developed for determination of metoprolol tartarate and hydrochlorothiazide in human plasma using paracetamol as an internal standard. The analytical technique used for method development was high-performance thin-layer chromatograph...
Plasma, Estudio de Validación, Metoprolol/análisis, Hidroclorotiazida/análisis, Cromatografía en Capa Delgada/métodos, Estudios de Validación como Asunto
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