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Justificativa e Desenho do Ensaio Clínico Randomizado COVID-19 Outpatient Prevention Evaluation (COPE - Coalition V): Hidroxicloroquina vs. Placebo em Pacientes Não Hospitalizados

Oliveira Junior, Haliton Alves de; Ferri, Cleusa P; Boszczowski, Icaro; Oliveira, Gustavo B. F; Cavalcanti, Alexandre B; Rosa, Regis G; Lopes, Renato D; Azevedo, Luciano C. P; Veiga, Viviane C; Berwanger, Otavio; Avezum, Álvaro.
Arq. bras. cardiol; 118 (2), 2022
Resumo Fundamento Apesar da necessidade de opções terapêuticas específicas para a doença do coronavírus 2019 (covid-19), ainda não há evidências da eficácia de tratamentos específicos no contexto ambulatorial. Há poucos estudos randomizados que avaliam a hidroxicloroquina (HCQ) em pacientes...
COVID-19/tratamiento farmacológico, Hidroxicloroquina/efectos adversos, Hidroxicloroquina/uso terapéutico, Pacientes Ambulatorios, SARS-CoV-2, Resultado del Tratamiento
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Sales of "COVID kit" drugs and adverse drug reactions reported by the Brazilian Health Regulatory Agency

Hentschke-Lopes, Marina; Botton, Mariana R.; Borges, Pâmella; Freitas, Martiela; Mancuso, Aline Castello Branco; Matte, Ursula.
Cad. Saúde Pública (Online); 38 (7), 2022
Off-label use of azithromycin, hydroxychloroquine, and ivermectin (the "COVID kit") has been suggested for COVID-19 treatment in Brazil without clinical or scientific evidence of efficacy. These drugs have known adverse drug reactions (ADR). This study aimed to analyze if the sales of drugs in the "COVID...
Azitromicina/efectos adversos, Brasil/epidemiología, COVID-19/tratamiento farmacológico, Infecciones por Coronavirus/tratamiento farmacológico, Infecciones por Coronavirus/epidemiología, Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiología, Hidroxicloroquina/efectos adversos, Ivermectina/efectos adversos, Pandemias, Neumonía Viral/tratamiento farmacológico, Neumonía Viral/epidemiología
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Outcomes associated with Hydroxychloroquine and Ivermectin in hospitalized patients with COVID-19: a single-center experience

Ferreira, Roberto Muniz; Beranger, Renata Wanderley; Sampaio, Pedro Paulo Noguères; Mansur Filho, João; Lima, Ricardo Antônio Correia.
Rev. Assoc. Med. Bras. (1992, Impr.); 67 (10), 2021
SUMMARY OBJECTIVE: Hydroxychloroquine and Ivermectin are advocated as potential treatments for coronavirus disease 2019 (COVID-19) despite the lack of supportive clinical evidence. In this study, outcomes associated with Hydroxychloroquine and/or Ivermectin were determined in a series of patients with c...
COVID-19, Hidroxicloroquina/efectos adversos, Ivermectina, Estudios Retrospectivos, SARS-CoV-2, Resultado del Tratamiento
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The impact of hydroxychloroquine and azithromycin on the corrected qt interval in patients with the novel Coronavirus disease 2019

Murat, Bektas; Akgun, Hakan; Akarsu, Muhittin; Ozmen, Ahmet; Murat, Selda.
Rev. Assoc. Med. Bras. (1992); 67 (7), 2021
SUMMARY OBJECTIVE: With the coronavirus disease 2019 (COVID-19) continuing to spread all over the world, although there is no specific treatment until now, hydroxychloroquine and azithromycin have been reported to be effective in recent studies. Although long-term use of hydroxychloroquine and azithromy...
Azitromicina/efectos adversos, COVID-19/tratamiento farmacológico, Quimioterapia Combinada, Electrocardiografía, Hidroxicloroquina/efectos adversos, Estudios Retrospectivos, SARS-CoV-2
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Evaluation of retinal and choroidal microvascular changes in patients who received hydroxychloroquine by optical coherence tomography angiography

Cinar, Esat; Yuce, Berna; Aslan, Fatih.
Arq. bras. oftalmol; 84 (1), 2021
ABSTRACT Purpose: The aim of the study is to evaluate the retinal and choroidal microvascular changes via optical coherence tomography angiography in patients who received hydroxy­chloroquine. Methods: In total, 28 eyes of 28 patients (24 females, and 4 males) receiving treatment with hydroxy­chloroq...
Hidroxicloroquina, Tomografía de Coherencia Óptica, Coroides/diagnóstico por imagen, Estudios Transversales, Angiografía con Fluoresceína, Hidroxicloroquina/efectos adversos, Vasos Retinianos/diagnóstico por imagen, Agudeza Visual
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Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19

Lamback, Elisa Baranski; Oliveira, Monica Amorim de; Haddad, Andrea Ferreira; Vieira, André Filipe Marcondes; Ferreira Neto, Armando Leão; Maia, Taciana da Silva; Chrisman, Juliana de Rezende; Spineti, Pedro Pimenta de Mello; Mattos, Marco Antonio de; Costa, Eduardo.
Braz. j. infect. dis; 25 (2), 2021
ABSTRACT Objectives: To assess the efficacy of hydroxychloroquine in combination with azithromycin in terms of clinical and biochemical outcomes in adult patients with COVID-19 hospitalized for acute respiratory distress syndrome (ARDS), and to describe the occurrence of adverse events. Method: Retrosp...
Azitromicina/efectos adversos, Brasil, COVID-19/tratamiento farmacológico, Quimioterapia Combinada, Hidroxicloroquina/efectos adversos, Persona de Mediana Edad, Estudios Retrospectivos, SARS-CoV-2
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El tratamiento del COVID-19 con hidroxicloroquina se asoció con aumento de la mortalidad y la cloroquina no mostró beneficios
Treatment of COVID-19 with hydroxychloroquine was associated with increased mortality and chloroquine showed no benefits

Cabrera, Victoria Sol; Ciapponi, Agustín.
Evid. actual. práct. ambul; 24 (2), 2021
Cloroquina/administración & dosificación, Cloroquina/efectos adversos, Comorbilidad, COVID-19/complicaciones, COVID-19/mortalidad, COVID-19/tratamiento farmacológico, COVID-19/virología, Hidroxicloroquina/administración & dosificación, Hidroxicloroquina/efectos adversos, Metaanálisis como Asunto, Participación del Paciente/estadística & datos numéricos, Terapia Combinada/efectos adversos, Terapia Combinada/métodos, SARS-CoV-2
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Cloroquina e hidroxicloroquina: medicamentos potencialmente inapropriados a idosos?

Gorzoni, Milton.
Geriatr., Gerontol. Aging (Online); 14 (4), 2020
INTRODUÇÃO: Medicamentos potencialmente inapropriados a idosos (MPII) provocam mais efeitos adversos do que benefícios. Os critérios de Beers (CB) da American Geriatrics Society 2019 (CB2019) consideraram cinco situações clínicas como MPII. A análise de medicamentos por essas situações pode aux...
Cloroquina/efectos adversos, Hidroxicloroquina/efectos adversos, Lista de Medicamentos Potencialmente Inapropiados, Prescripción Inadecuada/efectos adversos, Enfermedad Iatrogénica/prevención & control, Salud del Anciano, Envejecimiento/fisiología
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Seguridad de la cloroquina y la hidroxicloroquina para el tratamiento de pacientes con COVID-19
Safety of chloroquine and hydroxychloroquine for treating COVID-19 patients

Rodríguez Venegas, Elia de la Caridad; Hernández-García, Omar Luis; Denis Piedra, Daniel Alejandro.
Rev. cuba. med; 59 (3), 2020
Introducción: La cloroquina y su análogo hidroxicloroquina han mostrado presentar efectos antivirales y antiinflamatorios, por lo que podría ser una alternativa de tratamiento ante el nuevo coronavirus SARS-CoV-2. Objetivo: Describir seguridad de la cloroquina e hidroxicloroquina para el tratamient...
Infecciones por Coronavirus/tratamiento farmacológico, Cloroquina/uso terapéutico, Hidroxicloroquina/uso terapéutico, Cloroquina/efectos adversos, Hidroxicloroquina/efectos adversos, COVID-19/epidemiología
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