LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea

Pedrosa, Alano Martins; Barbosa, Maritza Cavalcante; Santos, Thayna Nogueira dos; Leal, Luzia Kalyne Almeida Moreira; Lopes, Amanda de Araújo; Elias, Darcielle Bruna Dias; Sasahara, Greyce Luri; Cavalcanti, Bruno Coêlho; Gonçalves, Romélia Pinheiro.

Braz. j. pharm. sci; 50 (2), 2014

Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on and potential toxicity to other blood cells such as ne...

Citotoxicidad Celular Dependiente de Anticuerpos/fisiología, Neutrófilos/clasificación, Anemia de Células Falciformes/fisiopatología, Hidroxiurea/análisis, Daño del ADN, ADN

Fulltext

Standardization method for measurement of hydroxyurea by Ultra High Efficiency Liquid Chromatography in plasma of patients with sickle cell disease

Sickle cell anemia (SCA) is a recessively inherited disease characterized by chronic hemolytic anemia, chronic inflammation, and acute episodes of hemolysis. Hydroxyurea (HU) is widely used to increase the levels of fetal hemoglobin (HbF). The objective of this study was to standardize and validate a met...