SUMMARY: Diabetes mellitus can lead to structural disorders in the brain. One of the most common complications of diabetes, diabetic neuropathy is associated with central nervous system disorders. Aloe vera has anti-diabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate t...
Diabetes Mellitus Experimental/tratamiento farmacológico,
Aloe/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Hipocampo/efectos de los fármacos,
Factor de Crecimiento Nervioso/efectos de los fármacos,
Administración Oral,
Proteínas Tirosina Quinasas Receptoras/efectos de los fármacos,
Proteínas Tirosina Quinasas Receptoras/genética,
Factor de Crecimiento Nervioso/genética,
Receptor de Factor de Crecimiento Nervioso/efectos de los fármacos,
Receptor de Factor de Crecimiento Nervioso/genética,
Ratas Wistar,
Reacción en Cadena en Tiempo Real de la Polimerasa
SUMMARY: This study aims to investigate the Effects of Titanium dioxide nanoparticles (TiO2 NPs) on the stereological parameters in the dentate gyrus and the morphology of granular hippocampal neurons in adult mice. Adult male mice (n=20, weight average: 45 g) were randomly divided into four groups inclu...
SUMMARY: Herbal extracts used for treatment of diabetes has focused mostly on the hypoglycaemic and anti-oxidant property.There are no studies which focused on its effect on dendritic architecture of pyramidal neurons of hippocampus caused by diabetes. This study was taken up to explore the effect of adm...
Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not wel...
Antidepressants use during pregnancy was associated with an increased risk of autism spectrum disorders. Animal models based on early life alterations in serotonin availability replicate some of the anatomical and behavioral abnormalities observed in autistic individuals. In recent years there has been a...
Citalopram/efectos adversos,
Citalopram/farmacología,
Antidepresivos/efectos adversos,
Antidepresivos/farmacología,
Hipocampo/efectos de los fármacos,
Hipocampo/citología,
Efectos Tardíos de la Exposición Prenatal,
Recuento de Células,
Factores Sexuales,
Trastorno Autístico/inducido químicamente,
Conducta Animal/efectos de los fármacos,
Ratas Sprague-Dawley,
Hipocampo/crecimiento & desarrollo,
Células Piramidales/efectos de los fármacos,
Animales Recién Nacidos
Abstract Background Adenosine A1 receptor (AA1R) is widely present in the central nervous system, exerting brain protective antiepileptic effects, mainly by binding corresponding G proteins. We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpin...
Agonistas del Receptor de Adenosina A1/farmacología,
Apoptosis/efectos de los fármacos,
Modelos Animales de Enfermedad,
Epilepsia/tratamiento farmacológico,
Hipocampo/efectos de los fármacos,
Hipocampo/patología,
Cloruro de Litio/toxicidad,
Neuronas/patología,
Fármacos Neuroprotectores/farmacología,
Pilocarpina/toxicidad,
Ratas Sprague-Dawley,
Factores de Tiempo
Abstract Background and objectives: Developing brain is more vulnerable to environmental risk than is the developed brain. We evaluated the effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus using stereological methods. Methods: Eighteen neonatal m...
SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components ...
Epilepsia/tratamiento farmacológico,
Marsileaceae/química,
Enfermedad Crónica,
Alcoholes Grasos/administración & dosificación,
Ácidos Grasos,
Hipocampo/efectos de los fármacos,
Memoria Espacial/efectos de los fármacos,
Región CA3 Hipocampal/efectos de los fármacos,
Ratas Wistar,
Pentilenotetrazol/efectos adversos,
Alcoholes Grasos/aislamiento & purificación,
Epilepsia/inducido químicamente,
Células Piramidales,
Prueba del Laberinto Acuático de Morris
Abstract Purpose To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia. Methods Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats i...
Alcaloides/farmacología,
Anestesia/efectos adversos,
Anestésicos por Inhalación/efectos adversos,
Ensayo de Inmunoadsorción Enzimática,
Hipocampo/efectos de los fármacos,
Hipocampo/metabolismo,
Interleucina-1beta/análisis,
Interleucina-6/análisis,
Isoflurano/efectos adversos,
Aprendizaje por Laberinto,
Factores de Crecimiento Nervioso/análisis,
Factores de Crecimiento Nervioso/efectos de los fármacos,
Fármacos Neuroprotectores/farmacología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Sesquiterpenos/farmacología
BACKGROUND: Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target. METHODS: HT22 cells were cultured in 25 or 50 mM ...
Hipocampo/efectos de los fármacos,
Factor 2 Relacionado con NF-E2/agonistas,
Neuroprotección,
Glucosa/toxicidad,
Western Blotting,
Línea Celular,
Electroforesis en Gel de Campo Pulsado,
Técnica del Anticuerpo Fluorescente,
Hipocampo/citología,
Especies Reactivas de Oxígeno,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo
