LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine

DAMAZIO, LOUYSE S; SILVEIRA, FLÁVIA R; CANEVER, LARA; CASTRO, ADALBERTO A DE; ESTRELA, JADNE M; BUDNI, JOSIANE; ZUGNO, ALEXANDRA I.

An. acad. bras. ciênc; 89 (2), 2017

ABSTRACT Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) ...

Acetilcolinesterasa/análisis, Acetilcolinesterasa/efectos de los fármacos, Acetilcolinesterasa/fisiología, Antioxidantes/farmacología, Ácido Ascórbico/farmacología, Cuerpo Estriado/efectos de los fármacos, Cuerpo Estriado/enzimología, Suplementos Dietéticos, Modelos Animales de Enfermedad, Antagonistas de Aminoácidos Excitadores, Hipocampo/efectos de los fármacos, Hipocampo/enzimología, Ketamina, Locomoción/efectos de los fármacos, Locomoción/fisiología, Esquizofrenia/enzimología, Esquizofrenia/prevención & control

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Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons

BACKGROUND: Wnt-5a is a member of the WNT family of secreted lipoglycoproteins, whose expression increases during development; moreover, Wnt-5a plays a key role in synaptic structure and function in the adult nervous system. However, the mechanism underlying these effects is still elusive. MicroRNAs (miR...