RESUMO Pesquisas recentes demonstram que o hipocampo apresenta uma redução de volume no final da idade adulta, mantendo uma estreita relação com o declínio cognitivo. A aquisição da imagem por diversos métodos de medição de volume nos leva a encontrar na ressonância magnética o método de des...
Intermittent fasting diet (IF) as a restrictive regimen prevents neural degeneration and stimulates overexpression of various neurotropic factors in the hippocampus of animal models. This study evaluates the potential effect of the IF in the prevention of learning and memory dysfunction and improving the...
Objective: Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients. Methods: In the present study, structural magnetic resonance imaging brain scans were ac...
Abstract Background Adenosine A1 receptor (AA1R) is widely present in the central nervous system, exerting brain protective antiepileptic effects, mainly by binding corresponding G proteins. We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpin...
Agonistas del Receptor de Adenosina A1/farmacología,
Apoptosis/efectos de los fármacos,
Modelos Animales de Enfermedad,
Epilepsia/tratamiento farmacológico,
Hipocampo/efectos de los fármacos,
Hipocampo/patología,
Cloruro de Litio/toxicidad,
Neuronas/patología,
Fármacos Neuroprotectores/farmacología,
Pilocarpina/toxicidad,
Ratas Sprague-Dawley,
Factores de Tiempo
Abstract Introduction: Major depressive disorder (MDD), an incapacitating mental disorder, is characterized by episodes of at least 2 weeks of apparent changes in mood, cognition, and neurovegetative functions. Many neuroimaging studies using magnetic resonance imaging (MRI) have examined morphometric c...
ABSTRACT Neurocysticercosis is one of the most common risk factors for epilepsy but its association with drug-resistant epilepsy remains uncertain. Conjectures of an association with drug-resistant epilepsy have been fueled by reports of an association between calcific neurocysticercosis lesions (CNL) an...
Vascouto, Helena Dresch;
Thais, Maria Emília Rodrigues de Oliveira;
Osório, Camila Moreira;
Ben, Juliana;
Claudino, Lucia Sukys;
Hoeller, Alexandre Ademar;
Markowitsch, Hans J;
Wolf, Peter;
Lin, Katia;
Walz, Roger.
ABSTRACT Sleepiness and cognitive impairment are common symptoms observed in patients with epilepsy. We investigate whether self-reported sleepiness is associated with cognitive performance in patients with refractory mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Seventy-one consecu...
Anticonvulsivantes/uso terapéutico,
Estudios de Casos y Controles,
Cognición/fisiología,
Demografía,
Epilepsia Refractaria/fisiopatología,
Escolaridad,
Epilepsia del Lóbulo Temporal/tratamiento farmacológico,
Epilepsia del Lóbulo Temporal/fisiopatología,
Epilepsia del Lóbulo Temporal/psicología,
Hipocampo/patología,
Pruebas Neuropsicológicas,
Esclerosis/complicaciones,
Autoinforme,
Somnolencia
Unbalanced nutrition during perinatal period causes varying degrees of perturbations in the metabolism and cognitive functions of offspring. The aim of this study was to investigate effects of maternal and postweaning high-fat diet (HFD) exposure on the growth parameters, hippocampal functions and morpho...
ABSTRACT The purpose of this study was to determine the effects of the high consumption of sucrose on the levels of DNA damage in blood, hippocampus and bone marrow of rats. Male Wistar rats were treated for 4 months with sucrose (10% for 60 initial days and 34% for the following 60 days) in drinking wat...
Médula Ósea/efectos de los fármacos,
Médula Ósea/patología,
Ensayo Cometa,
Daño del ADN,
Diabetes Mellitus Tipo 2/complicaciones,
Sacarosa en la Dieta/efectos adversos,
Modelos Animales de Enfermedad,
Hipocampo/efectos de los fármacos,
Hipocampo/patología,
Pruebas de Micronúcleos,
Ratas Wistar
Abstract Purpose: To evaluate the effects of HBO (Hyperbaric oxygen) and NGF (Nerve growth factor) on the long-term neural behavior of neonatal rats with HIBD (Neonatal hypoxic ischemic brain damage). Methods: The HIBD model was produced by ligating the right common carotid artery of 7 days old SD (Spr...
