Results: 275

Manejo de hiperglicemia inducida por corticoides en pacientes hospitalizados y ambulatorios
Management of corticosteroid-induced hyperglycemia in hospitalized patients and those attending outpatient clinics

Cambios rev. méd; 23 (2), 2024
La hiperglucemia inducida por corticoides es un aumento anormal de la glucosa en sangre debido al uso de glucocorticoides (GC). Su incidencia varía según la dosis, la forma de administración y factores individuales como la edad, el IMC y los antece-dentes familiares de diabetes. Según la ADA, entre e...

A comprehensive review on chemical and pharmacological potential of Synsepalum dulcificum (Schumach. & Thonn.) Daniell

The fruit of plant Synsepalum dulcificum (Schumach. & Thonn.) Daniell, is found native to tropical regions of West Africa, and vernacularly recognized as the “Miracle Fruit” by Africans. The property of the plant has traditionally been employed in many food industries...

Acidosis láctica en un paciente usuario de metformina

Rev. méd. Maule; 39 (1), 2024
Metformin is a hypoglycemic agent used as the first line for the treatment of non-insulin dependent Diabetes Mellitus. While it is a generally safe drug, it has an infrequent adverse reaction called lactic acidosis. We report a 49 year-old patient with non-insulin-requiring type 2diabetes who developed a...

Control metabólico de pacientes diabéticos tipo 2 tratados con empagliflozina: serie de casos

Medwave; 24 (3), 2024
INTRODUCCIÓN: La diabetes mellitus tipo 2 es una enfermedad de alta prevalencia y está asociada a mayor morbimortalidad. Debido al bajo porcentaje de compensación, se han buscado nuevas estrategias de tratamiento farmacológico, como los inhibidores del cotransportador sodio-glucosa tipo 2. OBJETIVO: ...

[Multidisciplinary consensus on the use of SGLT-2 inhibitors in chilean clinical practice using the GRADE methodology]

Rev. méd. Chile; 152 (2), 2024
The Chilean consensus on the use of SGLT-2 inhibitors (iSGLT-2) in clinical practice, jointly developed by the societies of Cardiology, Diabetes, Family Medicine, and Nephrology, strongly recommends the use of these drugs in people with heart failure with reduced ejection fraction, type 2 diabetes mellit...

Synthesis and evaluation of 2-phenylamino-1, 4-naphthoquinones derivatives as potential hypoglycaemic agents

Braz. j. biol; 84 (), 2024
Due to the severe side effects revealed by most of the currently used antidiabetic medicines, search for finding new and safe drugs to manage diabetes is continued. Naphthoquinones possessing strong antioxidant properties have been employed as candidates for diabetes therapy. Present study is aimed at fi...

Toma de posición. Efecto de los iSGLT-2 sobre la presión arterial, el daño vascular, la enfermedad renal y el riesgo cardiovascular asociado

Un nuevo y sorprendente paradigma se ha conformado con la llegada de las “gliflozinas”. Más allá de su acción antihiperglucémica, estos fármacos han impactado centralmente en la terapéutica de las alteraciones cardio-vásculo-reno-metabólicas responsables de las en...

Comparative efficacy of tirzepatide, teneligliptin, and empagliflozin in Hba1c reduction in patients with type 2 diabetes: a systematic review and meta-analysis

This study’s objective was to evaluate the effectiveness of three different families of drugs (Empagliflozin [an SGLT-2 inhibitor], Tirzepatide [a GLP-1 receptor co-agonist], and Teneligliptin [DPP-4 inhibitor] used in the treatment of type 2 diabetes in lowering HbA1...

Evaluation of the acute toxicity and antidiabetic activity of Coutoubea spicata “nicolau” ethanolic extract and ethyl acetate fraction

In order to understand antidiabetic potential and toxicity, this study aimed to evaluate the acute toxicity and antidiabetic activity of ethanolic extract and ethyl acetate fraction obtained from Coutoubea spicata “nicolau” shoots. Chemical constituents and acute toxicity were investigated. In alloxa...

Metformin Inhibits ROS/TNF-alpha Axis-Mediated Chronic Kidney Disease Induced by TAA Independent of Leukocyte Infiltration in Association with the Inhibition of Kidney Injury Biomarkers

Int. j. morphol; 41 (4), 2023
SUMMARY: The toxic effects of thioacetamide (TAA) and carbon tetrachloride on the human body are well recognized. In this study, we examined whether TAA intoxication can induce kidney leukocyte infiltration (measured as leukocyte common antigen CD45) associated with the augmentation of the reactive oxyge...