The fruit of plant Synsepalum dulcificum (Schumach. & Thonn.) Daniell, is found native to tropical regions of West Africa, and vernacularly recognized as the “Miracle Fruit” by Africans. The property of the plant has traditionally been employed in many food industries...
Synsepalum/química,
Extractos Vegetales/uso terapéutico,
Extractos Vegetales/farmacología,
Frutas/química,
Hipoglucemiantes/farmacología,
Hipolipemiantes/farmacología,
Antineoplásicos/farmacología,
Antiinfecciosos/farmacología,
Antioxidantes/farmacología,
Supresores de la Gota/farmacología,
Anticonvulsivantes/farmacología
dos Santos, Jymmys Lopes;
Silva, Ana Mara de Oliveira e;
Souza, Lúcio Marques Vieira;
Pereira, Raquel Oliveira;
Lima, Clésio Andrade;
Abreu, Lucas Silva;
Montalvao, Monalisa Martins;
Correa, Cristiane Bani;
Rabelo, Thallita Kelly;
Duarte, Marcelo Cavalcante;
Aidar, Felipe Jose;
Tavares, Josean Fechine;
Estevam, Charles dos Santos;
Marçal, Anderson Carlos.
In order to understand antidiabetic potential and toxicity, this study aimed to evaluate the acute toxicity and antidiabetic activity of ethanolic extract and ethyl acetate fraction obtained from Coutoubea spicata “nicolau” shoots. Chemical constituents and acute toxicity were investigated. In alloxa...
Extractos Vegetales/química,
Extractos Vegetales/toxicidad,
Extractos Vegetales/farmacología,
Etanol,
Diabetes Mellitus/tratamiento farmacológico,
Gentianaceae/química,
Hiperglucemia/tratamiento farmacológico,
Hipoglucemiantes/química,
Hipoglucemiantes/farmacología,
Cromatografía Líquida de Alta Presión,
Flavonoides/análisis,
Fenoles/análisis,
Supervivencia Celular,
Ratas Wistar,
Peso Corporal/efectos de los fármacos,
Oxidación-Reducción/efectos de los fármacos,
Hipoglucemiantes/toxicidad
Abstract Degenerative diseases diabetes and oxidative stress constitute a major health concern worldwide. Medicinal plants are expected to provide effective and affordable remedies. The present research explored antidiabetic and antioxidant potential of extracts of Carissa opaca roots. Methanolic extract...
Nordihydroguaiaretic acid (NDGA) is a natural product obtained by the alkaline extraction of dried plants of Larrea tridentata species. Due to the biological properties presented, such as antioxidant, anti-inflammatory, antiviral and cytotoxic capacity, this compound is being increasingly studied. In thi...
Masoprocol/análisis,
Fenómenos Químicos,
Antioxidantes/farmacología,
Antivirales/farmacología,
Hipoglucemiantes/farmacología,
Modelos Animales,
Neoplasias,
Plantas/clasificación,
Productos Biológicos/análisis,
Toxicidad,
Técnicas In Vitro/métodos
Regginato, A;
Cunico, L;
Bertoncello, K T;
Schindler, M S Z;
Chitolina, R;
Marins, K;
Zanatta, A P;
Calisto, J F;
Oliveira, J V;
Magro, J D;
Zanatta, L.
Abstract Campomanesia xanthocarpa, a plant belonging to the Myrtaceae family, is popularly known as gabiroba. Leaves of gabiroba has been popularly used to treat various diseases, including inflammatory, renal, and digestive, among others. Additionally, studies have shown an effect to reduce blood choles...
Microsechium helleri (Cucurbitaceae) has been used in ethnopharmacological as a lotion to prevent hair loss, diuretic and cathartic, in the region of central Veracruz, Mexico is used as antidiabetic. The antioxidant properties of the hexanic (EHex), chloroformic (ECHCl3) and ethanolic (EEtOH) extracts, ...
Cucurbitaceae/química,
Antiinflamatorios/farmacología,
Hipoglucemiantes/farmacología,
Cardiotónicos/farmacología,
Extractos Vegetales/farmacología,
Medicina Tradicional,
México,
Antiinflamatorios/química,
Hipoglucemiantes/química,
Cardiotónicos/química,
Extractos Vegetales/química,
Depuradores de Radicales Libres,
Compuestos Fenólicos/análisis
La diabetes mellitus, la insuficiencia cardíaca y la enfermedad renal crónica tienen alta prevalencia en la población. Asimismo, estas patologías están comprendidas en un "círculo vicioso" porque comparten mecanismos fisiopatológicos que predisponen a su coexistencia en un mismo paciente, incremen...
Mahmood, Rashid;
Malik, Farnaz;
Shamas, Shazia;
Ahmed, Tanveer;
Kausar, Mehran;
Rubnawaz, Samina;
Ashfaq, Muhammad;
Hussain, Shahzad;
Green, Brian Desmond;
Mirza, Bushra.
The present study aimed to screen the Rhazya stricta Decne root for its antihyperglycemic and antioxidants potential through invitro assays along with phytochemical and elemental analyses. The crude extract was prepared through maceration and fractionated using solvent-solvent extraction technique. The s...
Apocynaceae/química,
Raíces de Plantas/química,
Hipoglucemiantes/farmacología,
Antioxidantes/farmacología,
Técnicas In Vitro,
Extractos Vegetales/farmacología,
Extractos Vegetales/química,
Hipoglucemiantes/química,
Antioxidantes/química,
Dipeptidil-Peptidasas y Tripeptidil-Peptidasas/antagonistas & inhibidores,
Glucemia/efectos de los fármacos,
Fenoles/análisis,
Flavonoides/análisis,
Espectroscopía Infrarroja por Transformada de Fourier,
Espectrofotometría Ultravioleta,
Fitoquímicos
Background: The harmful effects of type 2 diabetes mellitus and its complications have become a major global public health problem. In this study, the effects of Momordica charantia saponins (MCS) on lipid metabolism, oxidative stress, and insulin signaling pathway in type 2 diabetic rats were investigat...
Diabetes Mellitus Experimental/tratamiento farmacológico,
Momordica charantia/química,
Saponinas/uso terapéutico,
Saponinas/farmacología,
Ratas Wistar,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Resistencia a la Insulina,
Lípidos,
Glucemia/efectos de los fármacos,
Peso Corporal,
Hígado/efectos de los fármacos,
Páncreas/efectos de los fármacos
The therapeutic approaches for Type 2 Diabetes Mellitus rely most on the usage of oral hypoglycaemic drugs. These drugs have adverse side effects and hence alternative medicines are continuously explored. The present study intends to investigate the antidiabetic potential of the flavonoids present in Gra...
