Results: 4

Insulin signaling in the whole spectrum of GH deficiency

ABSTRACT GH is one of the insulin counterregulatory hormones which acts in the opposite way to insulin, increasing the glucose production by the liver and kidneys and decreasing glucose uptake from peripheral tissues, thus being a hyperglycemic hormone. When in excess, as in acromegaly, it induces glucos...

Growth hormone in the tumor microenvironment

ABSTRACT Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvi...

Primary growth hormone insensitivity syndrome - A case reporte

Aproximadamente 230 casos da síndrome de insensibilidade ao GH (síndrome de Laron) foram descritos até o presente, e destes, dois o foram no Brasil. Esta síndrome caracteriza-se por achados clínicos de deficiência severa de hormônio do crescimento, associados à níveis séricos elevados de GH. Es...