LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Osteoprotective properties of RNA-containing drug osteochondrin S on the model of insufficiency of sex hormones in rats

SUMMARY: The aim of the study was to evaluate the osteoprotective properties of RNA-containing drug Osteochondrin S on rats with experimental model of osteoporosis. Osteochondrin S contains yeast RNA and RNA of connective tissue of cattle. In order to model osteoporosis in rats bilateral ovariectomy was ...

Deficiency of sex hormones does not affect 17-ß-estradiol-induced coronary vasodilation in the isolated rat heart

Santos, R L; Lima, J T; Rouver, W N; Moysés, M R.

Braz. j. med. biol. res; 49 (5), 2016

The relaxation of coronary arteries by estrogens in the coronary vascular beds of naive and hypertensive rats has been well described. However, little is known about this action in gonadectomized rats. We investigated the effect of 17-ß-estradiol (E2) in coronary arteries from gonadectomized rats, as we...

Vasos Coronarios/efectos de los fármacos, Vasos Coronarios/fisiología, Endotelio Vascular/efectos de los fármacos, Endotelio Vascular/fisiología, Estradiol/farmacología, Hormonas Esteroides Gonadales/deficiencia, Corazón/efectos de los fármacos, Orquiectomía, Ovariectomía, Ratas Wistar, Vasodilatación/efectos de los fármacos, Vasodilatadores/farmacología

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