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Safe-by-design development of a topical patch for drug delivery

Vaz, Mafalda. B; Vitorino, Carla; Sousa, João J. S.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment...
Preparaciones Farmacéuticas/administración & dosificación, Dibujo, Adhesivos/análisis, Artritis/patología, Inflamación/patología, Técnicas In Vitro/métodos, Hidrogeles/análisis, Cooperación del Paciente, Ibuprofeno/agonistas
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Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans

Rocha, Letícia Fernandes da; Pippi, Bruna; Fuentefria, Alexandre Meneghello; Mezzari, Adelina.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were...
Ibuprofeno/agonistas, Itraconazol/antagonistas & inhibidores, Fluconazol/antagonistas & inhibidores, Cryptococcus neoformans/aislamiento & purificación, Anfotericina B/análogos & derivados, Preparaciones Farmacéuticas/análisis, Técnicas In Vitro/métodos
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