LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review

Leite, Oriete Gerin; Tagliolatto, Sandra; Souza, Elemir Macedo de; Cintra, Maria Letícia.

An. bras. dermatol; 95 (1), 2020

Abstract Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic circulation of pro-inflammatory cytokines. ...

Corticoesteroides/uso terapéutico, Antineoplásicos/efectos adversos, Biopsia, Fármacos Dermatológicos/uso terapéutico, Imiquimod/efectos adversos, Queratosis Actínica/tratamiento farmacológico, Metotrexato/uso terapéutico, Persona de Mediana Edad, Pitiriasis Rubra Pilaris/inducido químicamente, Pitiriasis Rubra Pilaris/tratamiento farmacológico, Pitiriasis Rubra Pilaris/patología, Resultado del Tratamiento

Fulltext

Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice

BACKGROUND: Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyper-proliferation and excessive inflammatory response are considered to be potential...