Sequence similarity between thyroid self-protein and hepatitis c virus polyprotein: possible triggering mechanism of autoimmune thyroiditis
Arq. gastroenterol; 53 (3), 2016
ABSTRACT Background - Exposure to viral antigens that share amino acid sequence similar with self- antigens might trigger autoimmune diseases in genetically predisposed individuals, and the molecular mimicry theory suggests that epitope mimicry between the virus and human proteins can activate autoimmun...
Autoantígenos/genética, Epítopos/genética, Técnicas de Genotipaje, Hepacivirus/genética, Hepacivirus/inmunología, Imitación Molecular/genética, Poliproteínas/genética, Homología de Secuencia de Aminoácido, Tiroiditis Autoinmune/inmunología, Tiroiditis Autoinmune/virología, Proteínas Virales/genética