INTRODUCTION: For the diagnosis of liver diseases, clinical criteria, biochemical, immunological and histological parameters are included. The autoimmune panel is an immunoblot that contemplates the detection of antibodies against 9 different hepatic antigens, which could guide the diagnosis of these pat...
Autoanticuerpos/sangre,
Enfermedades Autoinmunes/sangre,
Enfermedades Autoinmunes/diagnóstico,
Enfermedades Autoinmunes/inmunología,
Hepatitis Autoinmune/sangre,
Hepatitis Autoinmune/diagnóstico,
Hepatitis Autoinmune/inmunología,
Immunoblotting/métodos,
Cirrosis Hepática Biliar/sangre,
Cirrosis Hepática Biliar/diagnóstico,
Cirrosis Hepática Biliar/inmunología,
Hepatopatías/diagnóstico,
Hepatopatías/inmunología
Ferreira-Silva, Márcia M;
Pereira, Gilberto de Araújo;
Rodrigues-Júnior, Virmondes;
Meira, Wendell SF;
Basques, Fernando V;
Langhi-Júnior, Dante Mário;
Romanelli, Marcelo;
Umezawa, Eufrosina S;
Késper-Júnior, Norival;
Louzada-Neto, Francisco;
Bordin, José O;
Moraes-Souza, Helio.
ABSTRACT Background: The screening of Trypanosoma cruzi-infected blood donors using two serological techniques frequently leads to conflicting results. This fact prompted us to evaluate the diagnostic performance of four "in-house" immunodiagnostic tests and two commercially available enzyme-linked immu...
BACKGROUND: Molecular brain therapies require the development of molecular switches to control gene expression in a limited and regulated manner in time and space. Light-switchable gene systems allow precise control of gene expression with an enhanced spatio-temporal resolution compared to chemical induc...
SUMMARY: The expression of aquaporin-1 (AQP1) in choroid plexus and aquaporin-4 (AQP4) in astrocyte of the hippocampal formation (HF) was studied in the rat to determine the role of AQP1 and AQP4 in the pathophysiology of systemic hyponatremia (SH). SH was induced by coadministration of dextrose solution...
Abstract Background Anti-ribosomal P (anti-Rib-P) antibody is a specific serological marker for systemic lupus erythematosus (SLE) and routinely tested by targeting the common epitope of three ribosomal proteins of P0, P1 and P2. This study aimed to investigate if testing antibodies against individual r...
Background: Myostatin (MSTN) negatively regulates muscle mass and is a potent regulator of energy metabolism. However, MSTN knockout have affect mitochondrial function. This research assessed the mitochondrial energy metabolism of Mstn−/+ KO cells, and wondered whether the mitochondria biogenesis are a...
Mitocondrias/genética,
Mitocondrias/metabolismo,
Edición Génica,
Sistemas CRISPR-Cas,
Miostatina/genética,
Diferenciación Celular,
Mioblastos/metabolismo,
Mioblastos/citología,
MicroARNs,
Proliferación Celular,
Immunoblotting,
Citometría de Flujo,
Biogénesis de Organelos,
Músculo Esquelético/citología,
Músculo Esquelético/metabolismo
Abstract The aim of this study was to determine the prevalence of infection by Sarcocystis neurona in horses and identify potential risk factors. Were analyzed 427 samples from 36 farms in 21 municipalities in the Alagoas State, Brazil. Presence of anti-S. neurona antibodies was diagnosed by indirect imm...
Anticuerpos Antiprotozoarios/sangre,
Brasil/epidemiología,
Estudios Transversales,
Técnica del Anticuerpo Fluorescente Indirecta/veterinaria,
Enfermedades de los Caballos/diagnóstico,
Enfermedades de los Caballos/epidemiología,
Caballos,
Immunoblotting,
Prevalencia,
Factores de Riesgo,
Sarcocystis/inmunología,
Sarcocistosis/diagnóstico,
Sarcocistosis/epidemiología,
Sarcocistosis/veterinaria,
Estudios Seroepidemiológicos
Abstract INTRODUCTION We evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of non-A-C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014. METHODS Serum samples (n = 318) were tested using ELISA and immu...
Brasil,
Ensayo de Inmunoadsorción Enzimática,
Anticuerpos Antihepatitis/sangre,
Hepatitis E/diagnóstico,
Hepatitis E/epidemiología,
Virus de la Hepatitis E/inmunología,
Immunoblotting,
Inmunoglobulina G/sangre,
Inmunoglobulina M/sangre,
Prevalencia,
ARN Viral/sangre,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Estudios Retrospectivos,
Estudios Seroepidemiológicos
Loxoscelism is a severe human envenomation caused by Loxosceles spider venom. To the best of our knowledge, no study has evaluated the presence of antibodies against Loxosceles venom in loxoscelism patients without treatment with antivenom immunotherapy. We perform a comparative analysis for the presence...
Caires, A;
Fernandes, G S;
Leme, A M;
Castino, B;
Pessoa, E A;
Fernandes, S M;
Fonseca, C D;
Vattimo, M F;
Schor, N;
Borges, F T.
Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to eval...
Lesión Renal Aguda/inducido químicamente,
Lesión Renal Aguda/fisiopatología,
Lesión Renal Aguda/prevención & control,
Bosentán,
Creatinina/sangre,
Ciclosporina/toxicidad,
Antagonistas de los Receptores de Endotelina/farmacología,
Antagonistas de los Receptores de Endotelina/uso terapéutico,
Hemodinámica,
Immunoblotting,
Inmunohistoquímica,
Inmunosupresores/toxicidad,
Riñón/efectos de los fármacos,
Pirimidinas/farmacología,
Ratas Wistar,
Reproducibilidad de los Resultados,
Urea/sangre
