Engeletin is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity and suppresses lipid peroxidation. In the present study, we sought to elucidate the mechanistic basis for the neuroprotective and pro-angiogenic activity of engeltin in a human umbilical vein endothelia...
It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies. The present study investigated whether the anti-apoptotic effect can account for the neuroprotective action of ZNS on cerebral ischemia. Neuronal ...
Maia, Isaac Holanda Mendes;
Melo, Thaissa Pinto de;
Lima, Fabrício Oliveira;
Carvalho, João José de Freitas;
Montalverne, Francisco José Arruda;
Lopes Júnior, Edson;
Diógenes, Marcelo Bezerra;
Cunha, Thaís Saraiva Leão;
Queiroz, Bárbara Matos Almeida;
Tamietti, Marina Franciss;
Maia, Fernanda Martins.
ABSTRACT Background: Malignant infarction of the middle cerebral artery (MCA) occurs in a subgroup of patients with ischemic stroke and early decompressive craniectomy (DC) is one of its treatments. Objective: To investigate the functional outcome of patients with malignant ischemic stroke treated wi...
La terapia endovascular (TEV) es el tratamiento estándar del ataque cerebrovascular isquémico (ACVi) con oclusión de gran vaso (OGVC). Aún no se conoce si esos resultados pueden generalizarse a la práctica diaria. Se describen los resultados de la TEV en pacientes con ACVi por OGVC dentro de las 24 ...
Argentina,
Isquemia Encefálica/mortalidad,
Isquemia Encefálica/cirugía,
Procedimientos Endovasculares/métodos,
Procedimientos Endovasculares/mortalidad,
Infarto de la Arteria Cerebral Media/mortalidad,
Infarto de la Arteria Cerebral Media/cirugía,
Estudios Retrospectivos,
Factores de Riesgo,
Índice de Severidad de la Enfermedad,
Accidente Cerebrovascular/mortalidad,
Accidente Cerebrovascular/cirugía,
Factores de Tiempo,
Resultado del Tratamiento
This paper reports the development of a three-channel automatic speed-matching climbing training system that could train three rats at the same time for rehabilitation after an ischemic stroke. An infrared (IR) remote sensor was installed at the end of each channel to monitor the real-time position of a ...
ABSTRACT This study aimed to analyze the cerebellum of rats submitted to an experimental focal cerebral ischemia, by middle cerebral artery occlusion for 90 minutes, followed by reperfusion for 48 hours, associated with an alcoholism model. Methods Fifty adult Wistar rats were used, subdivided into fiv...
Alcoholismo/sangre,
Alcoholismo/patología,
Apoptosis,
Isquemia Encefálica/sangre,
Isquemia Encefálica/patología,
Caspasa 9/análisis,
Cerebelo/química,
Cerebelo/patología,
Inmunohistoquímica,
Infarto de la Arteria Cerebral Media,
MicroARNs/sangre,
Distribución Aleatoria,
Ratas Wistar,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Daño por Reperfusión/patología,
Factores de Tiempo
We report an 89-year-old male under oral anticoagulant therapy with a therapeutic international normalized ratio, presenting at the emergency room with right side hemiparesis and aphasia. Neuroimaging was compatible with an acute middle cerebral artery ischemic stroke. Anticoagulation was reverted with t...
Acenocumarol/efectos adversos,
Amlodipino/efectos adversos,
Infarto de la Arteria Cerebral Media/tratamiento farmacológico,
Metformina/efectos adversos,
Protrombina/administración & dosificación,
Accidente Cerebrovascular/tratamiento farmacológico,
Terapia Trombolítica/métodos,
Acenocumarol/administración & dosificación,
Administración Intravenosa,
Amlodipino/administración & dosificación,
Infarto de la Arteria Cerebral Media/etiología,
Metformina/administración & dosificación,
Accidente Cerebrovascular/etiología,
Tomografía Computarizada por Rayos X
Embolic stroke secondary to cardiac tumors is uncommon. However, 25-30% of cardiac tumors may cause systemic emboli. We report a 29-year-old male consulting for a sudden episode of aphasia and right hemiparesis, compatible with infarct of the left middle cerebral artery territory. Transthoracic echocardi...
Fibroma/complicaciones,
Neoplasias Cardíacas/complicaciones,
Enfermedades de las Válvulas Cardíacas/complicaciones,
Infarto de la Arteria Cerebral Media/etiología,
Ecocardiografía,
Fibroma/diagnóstico por imagen,
Fibroma/patología,
Fibroma/cirugía,
Neoplasias Cardíacas/diagnóstico por imagen,
Neoplasias Cardíacas/patología,
Neoplasias Cardíacas/cirugía,
Enfermedades de las Válvulas Cardíacas/diagnóstico por imagen,
Enfermedades de las Válvulas Cardíacas/cirugía,
Válvula Mitral,
Músculos Papilares,
Esternotomía
Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill ...
