LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori

Gonzalez Hormazabal, Patricio; Pelaez, Diana; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Suazo, Jose; Quiñones, Luis A; Varela, Nelson M; Castro, V. Gonzalo; Jara, Lilian; Berger, Zoltan.

Biol. Res; 54 (), 2021

BACKGROUND: Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TL...

Infecciones por Helicobacter/genética, Proteína Adaptadora de Señalización NOD1/genética, Neoplasias Gástricas/genética, Estudios de Casos y Controles, Islas Genómicas, Helicobacter pylori

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Increased expression of interleukin-6 gene in gastritis and gastric cancer

Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric disease and cancer. We investigated the gene and prot...