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Increased expression of interleukin-6 gene in gastritis and gastric cancer

Santos, M P; Pereira, J N; Delabio, R W; Smith, M A C; Payão, S L M; Carneiro, L C; Barbosa, M S; Rasmussen, L T.
Braz. j. med. biol. res; 54 (7), 2021
Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric disease and cancer. We investigated the gene and prot...
Mucosa Gástrica, Gastritis/genética, Infecciones por Helicobacter/genética, Helicobacter pylori, Interleucina-6/genética, Interleucina-8, Neoplasias Gástricas/genética
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NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori

Gonzalez ­Hormazabal, Patricio; Pelaez, Diana; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Suazo, Jose; Quiñones, Luis A; Varela, Nelson M; Castro, V. Gonzalo; Jara, Lilian; Berger, Zoltan.
Biol. Res; 54 (), 2021
BACKGROUND: Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TL...
Infecciones por Helicobacter/genética, Proteína Adaptadora de Señalización NOD1/genética, Neoplasias Gástricas/genética, Estudios de Casos y Controles, Islas Genómicas, Helicobacter pylori
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