LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Oxidative stress: therapeutic approaches for cervical cancer treatment

Silva, Gabriela Ávila Fernandes; Nunes, Rafaella Almeida Lima; Morale, Mirian Galliote; Boccardo, Enrique; Aguayo, Francisco; Termini, Lara.

Clinics; 73 (supl.1), 2018

OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human...

Antioxidantes/uso terapéutico, Apoptosis/efectos de los fármacos, Inhibidores Enzimáticos/uso terapéutico, Estrés Oxidativo/efectos de los fármacos, Infecciones por Papillomavirus/tratamiento farmacológico, Infecciones por Papillomavirus/metabolismo, Especies Reactivas de Oxígeno/metabolismo, Neoplasias del Cuello Uterino/tratamiento farmacológico, Neoplasias del Cuello Uterino/metabolismo, Neoplasias del Cuello Uterino/virología

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Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases

Clinics; 73 (supl.1), 2018

Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, v...