SUMMARY: To evaluate the histological adverse effects of alendronate administered systemically and topically in combination with orthodontic movement by intense force. Thirty-six 24-week-old female Wistar rats, ovariectomized, were used and divided into three groups (n = 12/group): control, locally treat...
Maxilar/patología,
Conservadores de la Densidad Ósea/efectos adversos,
Alendronato/efectos adversos,
Técnicas de Movimiento Dental/instrumentación,
Métodos de Anclaje en Ortodoncia,
Ratas Wistar,
Análisis de Varianza,
Ovariectomía,
Resorción Ósea/inducido químicamente,
Inflamación/inducido químicamente,
d0041640
BACKGROUND: G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study, we investigated the role of spinal neuronal GRK2 in electroacupuncture (EA) analges...
This study investigated the acute blockade of endogenous melatonin (MLT) using Luzindole with or without systemic lipopolysaccharide (LPS) challenge and evaluated changes in inflammatory and oxidative stress markers in the mouse jejunum. Luzindole is an MT1/MT2 MLT receptor antagonist. Both receptors occ...
Coelho-de-Souza, A N;
Alves-Soares, R;
Oliveira, H D;
Gomes-Vasconcelos, Y A;
Souza, P J C;
Santos-Nascimento, T;
Oliveira, K A;
Diniz, L R L;
Guimarães-Pereira, J;
Leal-Cardoso, J H.
Hyptis crenata, commonly known as "salva-do-Marajó", "hortelã-do-campo", and "hortelãzinha", is used in folk medicine in Northeast Brazil as tea or infusion to treat inflammatory diseases. Due to the pharmacological efficacy and the low toxicity of the essential oil of Hyptis crenata (EOHc), we decide...
OBJECTIVES: This study intended to explore the effect of T regulatory cells (Tregs) in the perinatal liver against LPS-induced inflammation in a preterm birth mouse model. Moreover, the role of adoptive Tregs on the inflammatory response induced by LPS was also studied. METHODS: Female BALB/C mice were ...
Acne is a kind of common, chronic skin condition caused by the inflammation of the sebaceous glands in hair follicles. Recent studies have demonstrated that baicalin (BA) possesses potential anti-inflammatory properties. In this study, we evaluated the anti-inflammatory activity of BA in vitro and in viv...
Dermatitis/tratamiento farmacológico,
Flavonoides,
Inflamasomas,
Inflamación/inducido químicamente,
Inflamación/tratamiento farmacológico,
Interleucina-1beta/metabolismo,
Sistema de Señalización de MAP Quinasas,
FN-kappa B/metabolismo,
Proteína con Dominio Pirina 3 de la Familia NLR,
Propionibacterium acnes/metabolismo,
Ratas Sprague-Dawley,
Transducción de Señal
Abstract Purpose: To evaluate the hyaluronic acid (HA) inflammatory reaction, fibroblasts, fibrosis and duration of effect in the dorsal region of tobacco-exposed rats. Methods: Ten Wistar rats were divided into two groups: tobacco-exposed-group (TEG;n=5) and air-control-group (CG;n=5). The TEG animal...
Modelos Animales de Enfermedad,
Espacio Epidural/efectos de los fármacos,
Espacio Epidural/patología,
Fibroblastos/efectos de los fármacos,
Fibroblastos/patología,
Fibrosis,
Ácido Hialurónico/efectos adversos,
Inflamación/inducido químicamente,
Inflamación/patología,
Exposición por Inhalación/efectos adversos,
Ratas Wistar,
Factores de Tiempo,
Nicotiana/efectos adversos,
Viscosuplementos/efectos adversos
Barbosa, S C M;
Pereira, V B M;
Wong, D V T;
Santana, A P M;
Lucetti, L T;
Carvalho, L L;
Barbosa, C R N;
Callado, R B;
Silva, C A A;
Lopes, C D H;
Brito, G A C;
Alencar, N M N;
Lima-Júnior, R C P.
Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti...
Amifostina/uso terapéutico,
Cricetinae,
Modelos Animales de Enfermedad,
Fluorouracilo/efectos adversos,
Inflamación/inducido químicamente,
Inflamación/patología,
Inflamación/prevención & control,
Sustancias Protectoras/uso terapéutico,
Estomatitis/inducido químicamente,
Estomatitis/patología,
Estomatitis/prevención & control,
Xerostomía/inducido químicamente,
Xerostomía/patología,
Xerostomía/prevención & control
Abstract Purpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intra-abdominal adhesions. Metho...
Antiinflamatorios/uso terapéutico,
Antioxidantes/uso terapéutico,
Modelos Animales de Enfermedad,
Flavonoides/efectos adversos,
Flavonoides/uso terapéutico,
Radicales Libres/análisis,
Inmunohistoquímica,
Inflamación/inducido químicamente,
Inflamación/patología,
Laparotomía,
Ganglios Linfáticos/efectos de los fármacos,
Ganglios Linfáticos/patología,
Estrés Oxidativo/efectos de los fármacos,
Enfermedades Peritoneales/etiología,
Enfermedades Peritoneales/prevención & control,
Peritoneo/patología,
Peritoneo/cirugía,
Extractos Vegetales,
Complicaciones Posoperatorias,
Ratas Wistar,
Especies Reactivas de Oxígeno/metabolismo,
Adherencias Tisulares/etiología,
Adherencias Tisulares/patología,
Adherencias Tisulares/prevención & control
Abstract Obturation of the root canal system aims to fill empty spaces, promoting hermetic sealing and preventing bacterial activity in periapical tissues. This should provide optimal conditions for repair, stimulating the process of biomineralization. An endodontic sealer should be biocompatible once it...
Materiales Biocompatibles/química,
Materiales Biocompatibles/farmacología,
Hidróxido de Calcio/química,
Hidróxido de Calcio/farmacología,
Cerámica/química,
Cerámica/farmacología,
Resinas Epoxi/química,
Resinas Epoxi/farmacología,
Inflamación/inducido químicamente,
Ensayo de Materiales,
Ratas Wistar,
Reproducibilidad de los Resultados,
Materiales de Obturación del Conducto Radicular/química,
Materiales de Obturación del Conducto Radicular/farmacología,
Salicilatos/química,
Salicilatos/farmacología,
Tejido Subcutáneo/efectos de los fármacos,
Tejido Subcutáneo/patología,
Factores de Tiempo
