ABSTRACT The Human Genome Project has significantly broadened our understanding of the molecular aspects regulating the homeostasis and the pathophysiology of different clinical conditions. Consequently, the field of nutrition has been strongly influenced by such improvements in knowledge - especially fo...
ABSTRACT Objective: To determine the relationships that smoking history has with inflammatory markers, metabolic markers, body composition, muscle strength, and cardiopulmonary capacity in current smokers. Methods: This was a cross-sectional study involving 65 smokers (age range: 18-60 years). On three...
Biomarcadores/análisis,
Biomarcadores/metabolismo,
Composición Corporal/efectos de los fármacos,
Índice de Masa Corporal,
Capacidad Cardiovascular,
Estudios Transversales,
Inflamación/metabolismo,
Monocitos/metabolismo,
Fuerza Muscular/efectos de los fármacos,
Fumadores,
Fumar/efectos adversos,
Fumar/metabolismo,
Triglicéridos/sangre,
Circunferencia de la Cintura
Antunes, M M;
Godoy, G;
de Almeida-Souza, C B;
da Rocha, B A;
da Silva-Santi, L G;
Masi, L N;
Carbonera, F;
Visentainer, J V;
Curi, R;
Bazotte, R B.
We previously reported that both the high-carbohydrate diet (HCD) and high-fat diet (HFD) given for two months promote lipid deposition and inflammation in the liver and brain of mice. The results obtained indicate a tissue-specific response to both diets. Herein, we compared the effects of HCD and HFD o...
França, E E T;
Gomes, J P V;
De Lira, J M B;
Amaral, T C N;
Vilaça, A F;
Júnior, M D S Paiva;
Júnior, U F Elihimas;
Júnior, M A V Correia;
Júnior, L A Forgiarini;
Costa, M J C;
Andrade, M A;
Ribeiro, L C;
De Castro, C M M B.
Early mobilization is beneficial for critically ill patients because it reduces muscle weakness acquired in intensive care units. The objective of this study was to assess the effect of functional electrical stimulation (FES) and passive cycle ergometry (PCE) on the nitrous stress and inflammatory cytome...
Biomarcadores/sangre,
Enfermedad Crítica/rehabilitación,
Enfermedad Crítica/terapia,
Citocinas/sangre,
Estimulación Eléctrica/métodos,
Inflamación/inmunología,
Inflamación/metabolismo,
Unidades de Cuidados Intensivos,
Terapia Pasiva Continua de Movimiento/métodos,
Estrés Nitrosativo/fisiología,
Estrés Oxidativo/fisiología,
Músculo Cuádriceps/fisiopatología,
Respiración Artificial/métodos
Atherosclerosis (AS) is a common vascular disease, which can cause apoptosis of vascular endothelial cells. Notoginsenoside R1 (NGR1) is considered an anti-AS drug. MicroRNAs (miRNAs) are believed to play a vital role in cell apoptosis and angiogenesis. This study aimed to explore the mechanism of NGR1 f...
Apoptosis/efectos de los fármacos,
Western Blotting,
Ensayo de Inmunoadsorción Enzimática,
Ginsenósidos/farmacología,
Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos,
Células Endoteliales de la Vena Umbilical Humana/metabolismo,
Inmunoprecipitación,
Inflamación/metabolismo,
Lipoproteínas LDL/metabolismo,
MicroARNs/efectos adversos,
MicroARNs/metabolismo,
FN-kappa B/antagonistas & inhibidores,
Estrés Oxidativo/efectos de los fármacos,
Especies Reactivas de Oxígeno,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal,
Receptor Toll-Like 4/antagonistas & inhibidores,
Activación Transcripcional,
Regulación hacia Arriba
BACKGROUND: Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of anti-inflammation. RESULTS: HIF-1α was reduced in SCI model rats and HIF-1α activa...
Santos, M J S;
Canuto, K M;
de Aquino, C C;
Martins, C S;
Brito, G A C;
Pessoa, T M R P;
Bertolini, L R;
de Sá Carneiro, I;
Pinto, D V;
Nascimento, J C R;
da Silva, B B;
Valença Jr, J T;
Guedes, M I F;
Owen, J S;
Oriá, R B.
Malnutrition is still considered endemic in many developing countries. Malnutrition-enteric infections may cause lasting deleterious effects on lipid metabolism, especially in children living in poor settings. The regional basic diet (RBD), produced to mimic the Brazilian northeastern dietary characteris...
Apolipoproteína A-I/sangre,
Apolipoproteína A-I/metabolismo,
Brasil,
Enfermedad Crónica,
Dieta/efectos adversos,
Inflamación/sangre,
Inflamación/metabolismo,
Inflamación/patología,
Hígado/metabolismo,
Desnutrición/sangre,
Desnutrición/metabolismo,
Desnutrición/patología,
Ratones Endogámicos C57BL
Abstract Obesity associated with systemic inflammation induces insulin resistance (IR), with consequent chronic hyperglycemia. A series of reactions are involved in this process, including increased release of proinflammatory cytokines, and activation of c-Jun N-terminal kinase (JNK), nuclear factor-kapp...
Abstract Background: Oxidative stress and inflammation are present in coronary artery disease (CAD) and are linked to the activation of the transcription nuclear factor kappa B (NF-κB). To attenuate these complications, transcription factors like nuclear factor erythroid 2-related factor 2 (Nrf2) a...
Biomarcadores/metabolismo,
Índice de Masa Corporal,
Enfermedad de la Arteria Coronaria/metabolismo,
Regulación de la Expresión Génica,
Inflamación/metabolismo,
Factor 2 Relacionado con NF-E2/metabolismo,
FN-kappa B/metabolismo,
Estrés Oxidativo,
PPAR delta/metabolismo,
PPAR-beta/metabolismo,
Reacción en Cadena de la Polimerasa,
ARN Mensajero/metabolismo
Abstract Introduction: Anemic patients with chronic kidney disease (CKD) can be divided into anemic patients without or with functional iron deficiency (FID). The increase in the number of cases of hemosiderosis in patients on hemodialysis (HD) attributed to excessive intravenous iron replacement has ca...
Administración Intravenosa,
Anemia/epidemiología,
Anemia/etiología,
Anemia Ferropénica/epidemiología,
Anemia Ferropénica/etiología,
Biomarcadores/metabolismo,
Brasil/epidemiología,
Estudios Transversales,
Hemosiderosis/epidemiología,
Inflamación/metabolismo,
Hierro/administración & dosificación,
Hierro/efectos adversos,
Óxido Nítrico/metabolismo,
Evaluación Nutricional,
Estrés Oxidativo/fisiología,
Prevalencia,
Diálisis Renal/efectos adversos,
Insuficiencia Renal Crónica/complicaciones
