NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice
Braz. j. med. biol. res; 51 (9), 2018
The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most frequently studied in the central nervous system and has been linked to neuropathic pain. In this study, a post-translational mechanism of microRNA (miR)-186 via regulating the expression of NLRP3 in the complete Freu...
Western Blotting, Modelos Animales de Enfermedad, Ensayo de Inmunoadsorción Enzimática, Adyuvante de Freund, Estudios de Asociación Genética, Inflamasomas/análisis, Inflamasomas/fisiología, Interleucina-18/análisis, Interleucina-18/metabolismo, Interleucina-1beta/análisis, Interleucina-1beta/metabolismo, Luciferasas, Ratones Endogámicos C57BL, MicroARNs/farmacología, Análisis por Micromatrices, Proteína con Dominio Pirina 3 de la Familia NLR/análisis, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, Distribución Aleatoria, Valores de Referencia, Factores de Tiempo, Neuralgia del Trigémino/tratamiento farmacológico