SUMMARY: The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (...
Metformina/farmacología,
Resveratrol/farmacología,
Tioacetamida/toxicidad,
Cirrosis Hepática/inducido químicamente,
Serina-Treonina Quinasas TOR,
Inflamación,
Factor de Necrosis Tumoral alfa,
Citocinas/antagonistas & inhibidores,
Sirolimus,
Inmunohistoquímica,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Cirrosis Hepática/tratamiento farmacológico
SUMMARY: Liver transplantation is the only available method to treat liver failure induced by chronic liver injury. We sought to determine whether the angiotensin-converting enzyme inhibitor, captopril, can inhibit the development of chronic liver injury induced by the hepatotoxic agent thioacetamide (TA...
Captopril/administración & dosificación,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Tioacetamida/toxicidad,
Inflamación,
Factor Nuclear 1-alfa del Hepatocito,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factor de Necrosis Tumoral alfa,
Inhibidores de la Metaloproteinasa de la Matriz,
Actinas,
Western Blotting,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Metaloproteinasa 9 de la Matriz,
Fibrosis
Abstract Objective: We aimed to evaluate the effect of radiofrequency turbinate reduction as an initial treatment on clinical improvement, inflammatory mediators, and remodeling process. Methods: Between July 2018- February 2020, 32 patients with moderate-severe persistent AR were randomly divided into...
Abstract Inflammation of periodontal tissues is the consequence of interaction between periodontal pathogens and immune system. This is associated with increased expression of inflammatory cytokines, which may exert destructive effect to the periodontal tissues when released over long period. The aim of ...
OBJECTIVES: To evaluate the diagnostic value of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the MMP-9/TIMP-1 ratio in fetal inflammatory response syndrome (FIRS), and determine a possible association with the incidence of bronchopulmonary dysplasia (BPD) and ...
BACKGROUND: Non-canonical Wnt pathways play important roles in liver fibrosis. Notum is a newly discovered inhibitor to Wnt proteins. This study was to investigate anti-fibrotic effects of Notum. METHODS: 53 patients with hepatitis B virus (HBV) infection as well as a cell co-culture system of LX-2 and H...
Esterasas/administración & dosificación,
Hepatitis B/complicaciones,
Cirrosis Hepática/prevención & control,
Proteína Wnt-5a/antagonistas & inhibidores,
Actinas/metabolismo,
Colágeno Tipo I/metabolismo,
Virus de la Hepatitis B/fisiología,
Cirrosis Hepática/metabolismo,
Cirrosis Hepática/virología,
MAP Quinasa Quinasa 4/metabolismo,
Factores de Transcripción NFATC/análisis,
Factores de Transcripción NFATC/metabolismo,
Inhibidor Tisular de Metaloproteinasa-1/metabolismo,
Proteína Wnt-5a/metabolismo,
Supervivencia Celular,
Transfección,
Replicación Viral,
Vía de Señalización Wnt
SUMMARY OBJECTIVE: This study aims at investigating the expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/ tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary disease (COPD) and their relationships with pulmonary...
Estudios de Casos y Controles,
Volumen Espiratorio Forzado/fisiología,
Hematoxilina,
Inmunohistoquímica,
Pulmón/irrigación sanguínea,
Metaloproteinasa 9 de la Matriz/metabolismo,
Persona de Mediana Edad,
Miocitos del Músculo Liso/metabolismo,
Arteria Pulmonar/metabolismo,
Enfermedad Pulmonar Obstructiva Crónica/metabolismo,
Enfermedad Pulmonar Obstructiva Crónica/fisiopatología,
Valores de Referencia,
Inhibidor Tisular de Metaloproteinasa-1/metabolismo,
Receptor Toll-Like 4/metabolismo,
Remodelación Vascular,
Capacidad Vital/fisiología
ABSTRACT Background: Gastric cancer is the 3rd most common cause of death in men and the 5th common in women worldwide. Today, surgery is the only curative therapy. Currently available advanced imaging modalities can predict R0 resection in most patients, but it can only be detected with certainty in t...
Adenocarcinoma/sangre,
Adenocarcinoma/patología,
Adenocarcinoma/cirugía,
Biomarcadores de Tumor/sangre,
Queratina-18/sangre,
Modelos Logísticos,
Metástasis Linfática/patología,
Metaloproteinasa 9 de la Matriz/sangre,
Estadificación de Neoplasias,
Valores de Referencia,
Estadísticas no Paramétricas,
Neoplasias Gástricas/sangre,
Neoplasias Gástricas/patología,
Neoplasias Gástricas/cirugía,
Inhibidor Tisular de Metaloproteinasa-1/sangre
Küchler, Erika Calvano;
Barreiros, Driely;
Silva, Raphaela Oliveira da;
Abreu, Júlia Guimarães Barcellos de;
Teixeira, Ellen Cardoso;
Silva, Raquel Assed Bezerra da;
Silva, Lea Assed Bezerra da;
Nelson Filho, Paulo;
Romano, Fábio Lourenço;
Granjeiro, José Mauro;
Antunes, Lívia Azeredo Alves;
Antunes, Leonardo Santos.
Abstract Anterior open bite (AOB) has a multifactorial etiology caused by the interaction of sucking habits and genetic factors. The aim of this study was to evaluate the association between AOB and polymorphisms in genes that encode Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). F...
Succión del Dedo,
Frecuencia de los Genes,
Genotipo,
Metaloproteinasa 2 de la Matriz/genética,
Metaloproteinasa 3 de la Matriz/genética,
Metaloproteinasa 9 de la Matriz/genética,
Modelos Genéticos,
Mordida Abierta/etiología,
Mordida Abierta/genética,
Polimorfismo de Nucleótido Simple,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Inhibidor Tisular de Metaloproteinasa-1/genética,
Inhibidor Tisular de Metaloproteinasa-2/genética
Abstract Background: Childhood obesity is associated with increased risk of atherosclerosis and cardiovascular disease in adulthood. Increased intima-media thickness (IMT) of the carotid artery is linked to the initiation and progression of the chronic inflammatory processes implicated in cardiovascular...
Antropometría,
Aterosclerosis/etiología,
Biomarcadores/sangre,
Arterias Carótidas/patología,
Grosor Intima-Media Carotídeo,
Estudios de Casos y Controles,
Estudios Transversales,
Metaloproteinasa 9 de la Matriz/sangre,
Obesidad Infantil/sangre,
Obesidad Infantil/complicaciones,
Obesidad Infantil/patología,
Valores de Referencia,
Medición de Riesgo,
Factores de Riesgo,
Estadísticas no Paramétricas,
Inhibidor Tisular de Metaloproteinasa-1/sangre
