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Clinical significance of p27 Kip1 expression in advanced ovarian cancer

Alrehaili, Amani A; AlMourgi, Majed; Gharib, Amal F; Elsawy, Wael H; Ismail, Khadiga Ahmed; Hagag, Howaida Mahmoud; Anjum, Farah; Raafat, Nermin.
Appl. cancer res; 40 (), 2020
Background: Ovarian cancer is the most common gynecological malignancy. In patients with advanced ovarian cancer, some biological parameters have prognostic implementations. P27kip1 is an inhibitor of a cycline-dependent kinase, its loss, can contribute to tumor progression. Objective: This study aimed t...
Neoplasias Ováricas/metabolismo, Inhibidor p27 de las Quinasas Dependientes de la Ciclina/metabolismo, Carcinoma Epitelial de Ovario/metabolismo, Terapia Neoadyuvante, Reacción en Cadena en Tiempo Real de la Polimerasa, Inmunohistoquímica, Pronóstico, Estadificación de Neoplasias, Neoplasias Ováricas/tratamiento farmacológico, Carcinoma Epitelial de Ovario/tratamiento farmacológico
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Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis

Yang, Ying; Yan, Wei; Liu, Zhuogang; Wei, Minjie.
Braz. j. med. biol. res; 52 (5), 2019
Multiple myeloma (MM) is a malignant neoplasm of plasma, and exhibits several harmful effects including osteolytic injuries, hypercalcemia, and immune dysfunction. Many patients with MM succumb to the underlying malignancy. An S-phase kinase-related protein 2 (Skp2) inhibitor, designated SKPin C1, has be...
Apoptosis, Ciclo Celular, Proliferación Celular/efectos de los fármacos, Proliferación Celular/fisiología, Inhibidor p27 de las Quinasas Dependientes de la Ciclina/metabolismo, Inhibidor p27 de las Quinasas Dependientes de la Ciclina/farmacología, Mieloma Múltiple/metabolismo, Mieloma Múltiple/fisiopatología, Proteínas Quinasas Asociadas a Fase-S/antagonistas & inhibidores, Proteínas Quinasas Asociadas a Fase-S/metabolismo, Proteínas Ubiquitinadas/metabolismo, Ubiquitinación/fisiología
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