Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression
Acta cir. bras; 33 (11), 2018
Abstract Purpose: To investigate the effect of oxymatrine on periodontitis in rats and related mechanism. Methods: Ninety SD rats were divided into control, model, 10, 20 and 40 mg/kg oxymatrine and tinidazole groups. The periodontitis model was established in later 5 groups. The 10, 20 and 40 mg/kg oxy...
Alcaloides/farmacología, Antiinflamatorios/farmacología, Índice de Placa Dental, Dinoprostona/sangre, Encía/patología, Interleucina-1beta/sangre, Metaloproteinasas de la Matriz/análisis, Metaloproteinasas de la Matriz/efectos de los fármacos, Periodontitis/tratamiento farmacológico, Periodontitis/metabolismo, Quinolizinas/farmacología, Distribución Aleatoria, Ratas Sprague-Dawley, Valores de Referencia, Reproducibilidad de los Resultados, Tinidazol, Inhibidores Tisulares de Metaloproteinasas/análisis, Inhibidores Tisulares de Metaloproteinasas/efectos de los fármacos, Resultado del Tratamiento, Factor de Necrosis Tumoral alfa/sangre