Genotyping single-nucleotide polymorphism CYP2C19*2, pharmacodynamic evaluation of high on-clopidogrel treatment platelet reactivity and the cardiologist
Arch. cardiol. Méx; 90 (4), 2020
Results: 8
Association of CYP2C19*2 polymorphism with clopidogrel resistance among patients with high cardiovascular risk in Northeastern Mexico
Arch. cardiol. Méx; 89 (4), 2019
abstract Objective: Oral antiplatelet drugs are a key to modern pharmacotherapy in cardiovascular atherothrombotic diseases. Clopidogrel (CLO) constitutes the main preventive treatment of atherothrombosis. However, a considerable inter-individual variation in CLO response has been documented, resulting ...
Alelos, Enfermedades Cardiovasculares/tratamiento farmacológico, Enfermedades Cardiovasculares/fisiopatología, Clopidogrel/administración & dosificación, Clopidogrel/farmacología, Citocromo P-450 CYP2C19/genética, Resistencia a Medicamentos/genética, México, Inhibidores de Agregación Plaquetaria/administración & dosificación, Inhibidores de Agregación Plaquetaria/farmacología, Polimorfismo de Nucleótido Simple, Factores de Riesgo
High Residual Platelet Reactivity during Aspirin Therapy in Patients with Non-St Segment Elevation Acute Coronary Syndrome: Comparison Between Initial and Late Phases
Arq. bras. cardiol; 113 (3), 2019
Abstract Background: High platelet reactivity (HPR) during therapy with acetylsalicylic acid (ASA) is a poor prognostic factor in acute coronary syndromes (ACS). The prevalence of HPR during ACS is greater than that reported in stable diseases. However, it is unclear whether this prevalence of HPR is a ...
Síndrome Coronario Agudo/tratamiento farmacológico, Aspirina/farmacología, Aspirina/uso terapéutico, Trastornos de las Plaquetas Sanguíneas/tratamiento farmacológico, Plaquetas/efectos de los fármacos, Plaquetas/metabolismo, Infarto del Miocardio sin Elevación del ST/fisiopatología, Inhibidores de Agregación Plaquetaria/farmacología, Inhibidores de Agregación Plaquetaria/uso terapéutico, Pruebas de Función Plaquetaria, Estudios Prospectivos, Factores de Riesgo
Is preoperative clopidogrel resistance a predictor of bleeding and risks in patients undergoing emergency cabg surgery?
Rev. bras. cir. cardiovasc; 33 (4), 2018
Abstract Objective: The aims of this study were to determine whether the detection of preoperative clopidogrel resistance in patients undergoing cardiac surgery while using clopidogrel could play a guiding role in the prediction of postoperative excessive bleeding, transfusion requirements, and risks an...
Transfusión Sanguínea, Clopidogrel/farmacología, Puente de Arteria Coronaria/efectos adversos, Resistencia a Medicamentos, Inhibidores de Agregación Plaquetaria/farmacología, Pruebas de Función Plaquetaria/métodos, Hemorragia Posoperatoria/diagnóstico, Hemorragia Posoperatoria/etiología, Valor Predictivo de las Pruebas, Periodo Preoperatorio, Estudios Prospectivos, Valores de Referencia, Medición de Riesgo/métodos, Factores de Riesgo, Estadísticas no Paramétricas
Linking the platelet antiaggregation effect of different strawberries species with antioxidants: metabolomic and transcript profiling of polyphenols
Bol. latinoam. Caribe plantas med. aromát; 17 (1), 2018
A comparative study of antioxidant properties, platelet antiaggregation activity and transcriptional analysis of flavonoid biosynthesis genes were performed in Fragaria x ananassa, F. vesca and F. chiloensis subsp chiloensis f. chiloensis and f. patagonica. Furthermore, differences in flavonoid content w...
Fragaria/química, Antioxidantes/farmacología, Inhibidores de Agregación Plaquetaria/farmacología, Flavonoides/análisis, Extractos Vegetales/farmacología, Antioxidantes/química, Extractos Vegetales/química, Flavonoides/genética, Flavonoides/metabolismo, Cromatografía Líquida de Alta Presión/métodos, Recuperación de Fluorescencia tras Fotoblanqueo, Reacción en Cadena en Tiempo Real de la Polimerasa, Expresión Génica, Antioxidantes/química, Depuradores de Radicales Libres
Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients
Braz. j. med. biol. res; 50 (1), 2017
Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture may have increased prev...
Subfamilia B de Transportador de Casetes de Unión a ATP/genética, Alelos, Arildialquilfosfatasa/genética, Aspirina/farmacología, Plaquetas/efectos de los fármacos, Enfermedad de la Arteria Coronaria/tratamiento farmacológico, Enfermedad de la Arteria Coronaria/genética, Citocromo P-450 CYP2C19/genética, Quimioterapia Combinada, Genotipo, Intervención Coronaria Percutánea, Inhibidores de Agregación Plaquetaria/farmacología, Polimorfismo Genético, Estudios Prospectivos, Ticlopidina/análogos & derivados, Ticlopidina/farmacología
Análise transcriptômica de miRNAs em pacientes sob dupla terapia de antiagregação
A terapia antiagregante é comumente indicada na prevenção e tratamento de doenças cardiovasculares. A dupla antiagregação com clopidrogrel e ácido acetilsalicílico (AAS) tem sido frequentemente adotada em pacientes com Doença Arterial Coronariana (DAC), mas apresenta ineficácia em uma parcela s...
Advances in pharmacological studies of silymarin
Mem. Inst. Oswaldo Cruz; 86 (supl.2), 1991
Silymarin is the flavonoids extracted from the seeds of Silybum marianum (L) Gearth as a mixture of three structural isomers: silybin, silydianin and silychristin, the former being the most active component. Silymarin protects liver cell membrane against hepatotoxic agents and improves liver function in ...