Results: 7

Inhibición de las actividades proteolítica y fosfolipasa A2 del veneno de Bothrops asper por el extracto etanólico de Neurolaena lobata (L) Cass

Saravia-Otten, Patricia; Hernández, Rosario; Marroquín, Nereida; García, Gabriela; Nave, Federico; Rochac, Lorena; Genovez, Vicente; Mérida, Max; Cruz, Sully M; Cáceres, Armando; Gutiérrez, Jose M.

Cienc. tecnol. salud; 8 (1), 2021

Neurolaena lobata es utilizada tradicionalmente en Centroamérica para tratar la mordedura de serpiente, pero su efectividad para contrarrestar el envenenamiento producido por Bothrops asper ha sido poco estudiada. Se evaluó la capacidad del extracto etanólico de sus hojas para inhibir las actividades ...

Bothrops, Mordeduras de Serpientes/tratamiento farmacológico, Extractos Vegetales/farmacología, Antivenenos/farmacología, Venenos de Crotálidos/antagonistas & inhibidores, Inhibidores de Fosfolipasa A2/farmacología, Extractos Vegetales/uso terapéutico, Plantas Medicinales, Guatemala, Medicina Tradicional, Proteolisis/efectos de los fármacos, Coagulación Sanguínea/efectos de los fármacos, Extractos Vegetales/química, Hojas de la Planta, Etanol/uso terapéutico, Electroforesis en Gel de Poliacrilamida

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Use of protein kinase C and phospholipase A2 inhibitors in bovine endometrial cells treated with estradiol and calcium ionophore

Maldonado, Mariângela Bueno Cordeiro; Henry, Francine Messias Ciríaco; Ferreira, Teissiane Fernanda de Vasconcelos; Mello, Barbara Piffero; Binelli, Mario; Membrive, Claudia Maria Bertan.

Braz. J. Vet. Res. Anim. Sci. (Online); 58 (), 2021

The release of endometrial prostaglandin-F2α (PGF2α) in bovine females can be induced in vivo by estradiol (E2). However, its role in this mechanism has not been clarified. We hypothesized that E2 stimulates the activity and abundance of protein kinase C (PKC) and phospholipase A2 (PLA2). Our objective...

Bovinos/fisiología, Proteína Quinasa C, Inhibidores de Fosfolipasa A2, Enfermedades Uterinas, Estradiol, Ionóforos de Calcio

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Identification and characterization of the first endogenous phospholipase A2 inhibitor from a non-venomous tropical snake, Boa constrictor (Serpentes: Boidae)

Fortes-Dias, Consuelo L; Macedo, Diego Henrique Fagundes; Barbosa, Rafaella Pereira; Souza-Silva, Gabriel; Ortolani, Paula Ladeira.

J. venom. anim. toxins incl. trop. dis; 26 (), 2020

Abstract Background: Endogenous phospholipase A2 inhibitors from snake blood (sbPLIs) have been isolated from several species around the world, with the primary function of self-protection against the action of toxic phospholipases A2. In American snakes, sbPLIs were solely described in pit vipers, in ...

Venenos Elapídicos, Inhibidores de Fosfolipasa A2, Serpientes, Viperidae, Fosfolipasas A2

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Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis

Bordon, Maria L. A. C; Laurenti, Márcia D; Ribeiro, Susan Pereira; Toyama, Marcos H; Toyama, Daniela de O; Passero, Luiz Felipe D.

J. venom. anim. toxins incl. trop. dis; 24 (), 2018

Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins ...

Inhibidores de Fosfolipasa A2/farmacología, Leishmania/efectos de los fármacos, Leishmania/parasitología, Técnicas In Vitro, Lactonas/antagonistas & inhibidores, Ratones Endogámicos BALB C, Macrófagos Peritoneales/efectos de los fármacos

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Alpha-type phospholipase A2 inhibitors from snake blood

Santos-Filho, Norival A; Santos, Claudia T.

J. venom. anim. toxins incl. trop. dis; 23 (), 2017

It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood. Venomous and nonvenomous snakes have PLA2 inhibitory proteins, called PLIs, in their blood serum. On...

Venenos de Serpiente, Fosfolipasas A2, Inhibidores de Fosfolipasa A2, Anticuerpos

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Preparation of monoclonal antibodies against gamma-type phospholipase A2 inhibitors and immunodetection of these proteins in snake blood

Li, Jingjing; Xiong, Ying; Sun, Shimin; Yu, Lehan; Huang, Chunhong.

J. venom. anim. toxins incl. trop. dis; 23 (), 2017

Background: Paracoccidioidomycosis (PCM) is a neglected systemic mycosis caused by a dimorphic fungus of the Paracoccidioides genus. The standard diagnosis is based on isolation of the fungi in culture, and by microscopic visualization of characteristic multiple budding yeast cells in biological samples....

Fosfolipasas A2, Anticuerpos Monoclonales, Serpientes, Inhibidores de Fosfolipasa A2

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Endogenous phospholipase A2 inhibitors in snakes: a brief overview

Campos, Patrícia Cota; Melo, Lutiana Amaral de; Dias, Gabriel Latorre Fortes; Fortes-Dias, Consuelo Latorre.

J. venom. anim. toxins incl. trop. dis; 22 (), 2016

The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not a...

Inhibidores de Fosfolipasa A2, Serpientes, Plasma, Sangre, Lectinas Tipo C

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