Se presenta un estudio observacional compasivo de seguimiento de 20 pacientes portadores de Fibrosis Pulmonar Idiopática tratados con Nintedanib, que muestra que Nintedanib es un medicamento en general bien tolerado, sin efectos adversos serios, que otorga una sobrevida más prolongada que la que cabrí...
Background: Before the advent of tyrosine kinase inhibitors (TKIs), patients with Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ALL) had a poor prognosis. The association of TKIs to intensive chemotherapy (CT) improved outcome. Aim: To evaluate results of an intensive CT protocol including TKI i...
Treistman, Natalia;
Nobre, Gabriela Maia;
Tramontin, Mariana Yoshii;
Silva, Gabriel Madeira Werberich da;
Herchenhorn, Daniel;
Araujo, Luiz Henrique de Lima;
Andrade, Fernanda Accioly de;
Corbo, Rossana;
Bulzico, Daniel;
Vaisman, Fernanda.
ABSTRACT Objective: The aim of this study was to describe the real-world experience multikinase inhibitors (MKI) in the treatment advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAIR) therapy. Subjects and methods: We reviewed the records of all patients with MKI-treat...
ABSTRACT The concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocations in lung adenocancers are very rare scenarios. Until now, 42 cases described in the literature have all been treated by different drugs. There is no overall consensus regarding the...
Adenocarcinoma/genética,
Neoplasias Pulmonares/genética,
Mutación/genética,
Genes erbB-1/genética,
Exones/genética,
Crizotinib/uso terapéutico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Docetaxel/uso terapéutico,
Cisplatino/uso terapéutico,
Antineoplásicos/uso terapéutico,
Neoplasias Pulmonares/tratamiento farmacológico,
Adenocarcinoma/tratamiento farmacológico
OBJECTIVES: Lung cancer is the leading cause of cancer-related deaths worldwide. However, factors associated with the survival of patients with advanced non-small-cell lung cancer (NSCLC) who received only hospice care are largely unclear. In this study, we aimed to determine the prognostic factors corre...
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/genética,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Receptores ErbB/genética,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/genética,
Neoplasias Pulmonares/patología,
Mutación,
Estadificación de Neoplasias,
Pronóstico,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Estudios Retrospectivos
Biological therapy dramatically changed the management of Ulcerative Colitis (UC). However, a significant number of these patients fail to respond or have secondary loss of response to this strategy. In this clinical situation, the options include intensification of anti-TNF therapy, the use of a second ...
OBJECTIVE: The occurrence of cryptic Philadelphia (Ph) chromosome translocation is rare in BCR-ABL1-positive acute lymphoblastic leukemia (BCR-ABL1+ ALL) and is of unknown significance in the tyrosine kinase inhibitor (TKI) era. METHODS: We retrospectively studied a series of adult patients receiving TK...
ABSTRACT Objective: Lung cancer is an important health problem due to its high incidence and mortality. The treatment of metastatic disease improved after the molecular pathways of cancer came to be known. However, targeted therapy is unavailable to many patients treated within the Brazilian Sistema Ún...
ABSTRACT BACKGROUND: Lung cancer is the fourth most common cancer in Brazil. In the 2000s, better understanding of molecular pathways led to development of epidermal growth factor receptor (EGFR)-targeted treatments that have improved outcomes. However, these treatments are unavailable in most Brazilia...
Brasil,
Presupuestos,
Análisis Costo-Beneficio/economía,
Receptores ErbB/economía,
Receptores ErbB/uso terapéutico,
Costos de la Atención en Salud,
Accesibilidad a los Servicios de Salud/economía,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/economía,
Neoplasias Pulmonares/mortalidad,
Terapia Molecular Dirigida/economía,
Inhibidores de Proteínas Quinasas/economía,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Años de Vida Ajustados por Calidad de Vida,
Quinazolinas/economía,
Quinazolinas/uso terapéutico,
Prorrateo de Riesgo Financiero/métodos,
Análisis de Supervivencia
ABSTRACT Janus kinases inhibitors have already been incorporated into the management of immune-mediated diseases, such as rheumatoid arthritis, and are being investigated for the treatment of psoriasis and inflammatory bowel diseases, both ulcerative colitis and Crohn's disease. Tofacitinib is an oral sm...
