Results: 60

Resistance to protease inhibitors and HIV-1 genetic variability in V3 region in people living with HIV/AIDS

One of the main characteristics of HIV-1 is its high genetic vari-ability and the occurrence of resistance mutations to antiretroviral therapy (ART), particularly in individuals who use these medica-tions for prolonged periods. In addition, HIV-1 has a high muta-tion rate in the env gene, particularly in...

Effect of phenylmethylsulfonyl fluoride, a protease inhibitor, on enamel surface remineralization

Braz. j. oral sci; 22 (), 2023
Phenylmethylsulfonyl fluoride (PMSF) is a protease inhibitor widely used in research, but fluoride is released during its action and this knowledge has been neglected in dental research. Aim: to evaluate if fluoride released by salivary protease action on PMSF affects enamel remineralization and fluoride...

A threefold approach including quantum chemical, molecular docking and molecular dynamic studies to explore the natural compounds from Centaurea jacea as the potential inhibitors for COVID-19

Braz. j. biol; 83 (), 2023
Abstract In the current report, we studied the possible inhibitors of COVID-19 from bioactive constituents of Centaurea jacea using a threefold approach consisting of quantum chemical, molecular docking and molecular dynamic techniques. Centaurea jacea is a perennial herb often used in folk medicines of ...

Nirmatrelvir-ritonavir (Paxlovid) para el tratamiento de pacientes con COVID-19: [2 de julio de 2022]

INTRODUCCIÓN: El nirmatrelvir es un inhibidor de la proteasa biodisponible por vía oral que es activo frente a MPRO, una proteasa viral que desempeña un papel esencial en la replicación viral al escindir las 2 poliproteínas virales.15 Ha demostrado actividad antiviral frente a todos los coronavirus ...

Nirmatrelvir-ritonavir (Paxlovid) para el tratamiento de pacientes con COVID-19: [17 de marzo de 2022]

INTRODUCCIÓN: El nirmatrelvir es un inhibidor de la proteasa que se administra por vía oral, que demostró ser activo frente a MPRO, una proteasa viral que desempeña un papel esencial en la replicación viral al escindir las 2 poliproteínas virales. 15 Además, ha demostrado actividad antiviral frent...

Ulinastatin alleviates early brain injury after intracerebral hemorrhage by inhibiting oxidative stress and neuroinflammation via ROS/MAPK/Nrf2 signaling pathway

Acta cir. bras; 37 (6), 2022
Purpose: Spontaneous intracerebral hemorrhage (ICH) is still a major public health problem, with high mortality and disability. Ulinastatin (UTI) was purified from human urine and has been reported to be anti-inflammatory, organ protective, and antioxidative stress. However, the neuroprotection of UTI in...

Sodium trimetaphosphate combined to calcium as a strategy to improve dentin-bonding interface

Braz. dent. sci; 25 (2), 2022
Objective: The aim of this study was to evaluate the effect of STMP as biomimetic analog of dentin matrix on the dentin bond strength submitted to artificial cariogenic challenge over time. Material and Methods: The total number of teeth used in the experiment was 60 teeth, which were divided into 6 grou...

Disfunción eréctil en personas con VIH – Revisión de alcance

Objetivo Exponer los factores que han sido asociados al desarrollo de disfunción eréctil (DE) en las personas con virus de la inmunodeficiencia humana (VIH) y cuál es la prevalencia de la disfunción eréctil en esta población. Métodos Se realizó una revisión de alcance utilizando las siguien...

Tratamiento Covid-19
Covid-19 treatment

The main treatment for patients with severe Covid-19 is to maintain adequate ventilatory support and monitor the possible progression of the disease. Therapeutic strategies such as High Flow Nasal Cannula, awake prone position, antithrombotic prophylaxis and the use ...

VIH y salud ósea
HIV and bone health

Actual. osteol; 17 (3), 2021
Con el advenimiento de la terapia antirretroviral, el pronóstico y la sobrevida de los pacientes infectados con el virus de la inmunodeficiencia humana (VIH) han cambiado de manera radical, por lo cual en la actualidad se evidencia un aumento en el riesgo de padecer enfermedad...