Results: 3

Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro

Braz. j. med. biol. res; 51 (11), 2018
Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling pathway. Sema3 proteins convey their regulatory sign...

Quality of bevacizumab (Avastin®) repacked in single-use glass vials for intravitreal administration

Arq. bras. oftalmol; 80 (2), 2017
ABSTRACT Purpose: Avastin® (bevacizumab) is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody given as an off-label drug by intravitreal administration for treatment of ocular diseases. The drug's clinical application and its cost-benefit profile has generated demand for its divisio...

Importância do domínio extracelular do receptor tirosina quinase Tie1 na angiogênese

Tie1 é um receptor tirosina quinase expresso em células endoteliais importante em angiogênese, formação de vasos sanguíneos a partir de vasos pré-existentes. Este receptor pertence a uma família pequena composta por apenas dois membros (Tie1 e Tie2) para os quais angiopoietinas foram identificada...