LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The use of aromatase inhibitors in boys with short stature: what to know before prescribing?

ABSTRACT Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in b...

Use of anastrozole in the chemoprevention and treatment of breast cancer: A literature review

Barros-Oliveira, Maria da Conceição; Costa-Silva, Danylo Rafhael; Andrade, Danielle Benigno de; Borges, Umbelina Soares; Tavares, Cléciton Braga; Borges, Rafael Soares; Silva, Janaína de Moraes; Silva, Benedito Borges da.

Rev. Assoc. Med. Bras. (1992, Impr.); 63 (4), 2017

Summary Aromatase inhibitors have emerged as an alternative endocrine therapy for the treatment of hormone sensitive breast cancer in postmenopausal women. The use of third-generation inhibitors represented by exemestane, letrozol and anastrozole is currently indicated. Anastrozole is a nonsteroidal comp...

Anastrozol, Antineoplásicos Hormonales/farmacocinética, Antineoplásicos Hormonales/uso terapéutico, Inhibidores de la Aromatasa/farmacocinética, Inhibidores de la Aromatasa/uso terapéutico, Neoplasias de la Mama/tratamiento farmacológico, Neoplasias de la Mama/prevención & control, Quimioprevención/métodos, Quimioterapia Adyuvante, Nitrilos/farmacocinética, Nitrilos/uso terapéutico, Posmenopausia, Reproducibilidad de los Resultados, Tamoxifeno/farmacocinética, Tamoxifeno/uso terapéutico, Resultado del Tratamiento, Triazoles/farmacocinética, Triazoles/uso terapéutico

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