The aim of this study was to identify the chemical composition of the Piper arboreum Aubl. essential oil (EO), and to evaluate its inhibitory activity in vitro against the enzymes butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). The EO was obtained by steam distillation of t...
Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the cholinergic deficit in Alzheimer’s disease (AD) patients. In the ...
Inhibidores de la Colinesterasa/farmacología,
Flavonoides/análisis,
Enfermedad de Alzheimer/tratamiento farmacológico,
Marruecos,
Fenoles/análisis,
Peroxidación de Lípido/efectos de los fármacos,
Antioxidantes/farmacología,
Rumex,
Taraxacum,
Hypericum,
Inhibidores de la Colinesterasa/química,
Antioxidantes/química,
Especies Reactivas de Oxígeno
Search for safe antioxidants and novel nutraceuticals urged to evaluate the antioxidant, anti-acetylcholine esterase and anti-lipoxygenase activity of various leaf extracts of Conocarpus lancifolius. Extraction was optimized from freeze dried plant extracts quenched with liquid nitrogen using water, et...
Combretaceae/química,
Extractos Vegetales/farmacología,
Extractos Vegetales/química,
Antioxidantes/farmacología,
Antioxidantes/química,
Fenoles/análisis,
Flavonoides/análisis,
Inhibidores de la Lipooxigenasa/farmacología,
Inhibidores de la Colinesterasa/farmacología,
Inhibidores de la Lipooxigenasa/química,
Inhibidores de la Colinesterasa/química,
Técnicas In Vitro,
Etanol,
Depuradores de Radicales Libres
Abstract This study reports the action of essential oils (EO) from five plants on the activity of native and recombinant acetylcholinesterases (AChE) from Rhipicephalus microplus. Enzyme activity of native susceptible AChE extract (S.AChE), native resistant AChE extract (R.AChE), and recombinant enzyme (...
Hippeastrum puniceum is a species that belongs to the Amaryllidaceae family. A particular characteristic of this family is the consistent and very specific presence of isoquinoline alkaloids, which have demonstrated a wide range of biological activities such as antioxidant, antiviral, antifungal, antipar...
Iqbal, Javed;
Rehman, Aziz-ur-;
Abbasi, Muhammad Athar;
Siddiqui, Sabahat Zahra;
Rasool, Shahid;
Ashraf, Muhammad;
Iqbal, Ambar;
Hamid, Sujhla;
Chohan, Tahir Ali;
Khalid, Hira;
Laulloo, Sabina Jhaumeer;
Shah, Syed Adnan Ali.
We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking studies explained the different types of interaction of the...
Simulación por Computador/clasificación,
Sulfonamidas/efectos adversos,
Aminoácidos/antagonistas & inhibidores,
Análisis de Datos,
Concentración 50 Inhibidora,
Bacillus subtilis/clasificación,
Espectroscopía de Protones por Resonancia Magnética/métodos,
Inhibidores de la Colinesterasa/farmacología,
Preparaciones Farmacéuticas/administración & dosificación,
Salmonella typhi/clasificación,
Albúmina Sérica Bovina,
Ureasa,
Tiourea
Chemical constituents and biological activities of the aerial parts of Piper erecticaule C.DC. have been studied for the first time. Fractionation and purification of the extracts afforded aristolactam AII (1), aristolactam BII (2), piperolactam A (3), piperolactam C (4), piperolactam D (5), together wit...
Piper/química,
Extractos Vegetales/química,
Alcaloides/farmacología,
Alcaloides/química,
Aporfinas/farmacología,
Aporfinas/química,
Lactamas/química,
Alcaloides Indólicos/química,
Terpenos/aislamiento & purificación,
Acetilcolinesterasa/efectos de los fármacos,
Inhibidores de la Colinesterasa/farmacología,
Inhibidores de la Colinesterasa/química
BACKGROUND: Microalgae are aquatic chlorophyll-containing organisms comprising unicellular microscopic forms, and their biomasses are potential sources of bioactive compounds, biofuels and food-based products. However, the neuroprotective effects of microalgal biomass have not been fully explored. In thi...
Chlorella/química,
Antioxidantes/farmacología,
Inhibidores de la Colinesterasa/farmacología,
Péptidos beta-Amiloides/antagonistas & inhibidores,
Amiloide/efectos de los fármacos,
Extractos Vegetales/farmacología,
Etanol,
Microalgas,
Biomasa,
Cromatografía de Gases y Espectrometría de Masas,
Fármacos Neuroprotectores,
Enfermedad de Alzheimer/prevención & control,
Fenoles/análisis,
Terpenos/análisis,
Extractos Vegetales/química,
Antioxidantes/química,
Espectroscopía Infrarroja por Transformada de Fourier,
Inhibidores de la Colinesterasa/química,
Esteroides/análisis,
Esteroles/análisis,
Ácidos Grasos/análisis
Abstract Objectives Reductions in diaphragm activity are associated with the postoperative development of atelectasis. Neostigmine reversal is also associated with increased atelectasis. We assessed the effects of neostigmine, sugammadex, and spontaneous reversal on regional lung ventilation and airway ...
Periodo de Recuperación de la Anestesia,
Inhibidores de la Colinesterasa/farmacología,
Pulmón/diagnóstico por imagen,
Pulmón/efectos de los fármacos,
Pulmón/fisiología,
Neostigmina/farmacología,
Bloqueo Neuromuscular,
Proyectos Piloto,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Respiración/efectos de los fármacos,
Sugammadex/farmacología
Abstract: INTRODUCTION: Dengue fever is a viral disease transmitted by the Aedes aegypti Linn. (1792) (Diptera: Culicidae) mosquito, which is endemic in several regions of Brazil. Alternative methods for the control of the vector include botanical insecticides, which offer advantages such as lower envir...
Aedes,
Anacardium/química,
Inhibidores de la Colinesterasa/farmacología,
Colinesterasas/efectos de los fármacos,
Técnicas In Vitro,
Insectos Vectores/efectos de los fármacos,
Insecticidas/aislamiento & purificación,
Insecticidas/farmacología,
Hígado/enzimología,
Malato Deshidrogenasa/antagonistas & inhibidores,
Ácidos Ricinoleicos/aislamiento & purificación,
Ácidos Ricinoleicos/farmacología,
Espectrofotometría Ultravioleta
