Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects
An. acad. bras. ciênc; 89 (3), 2017
ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe th...
Anestésicos Disociativos/farmacología, Conducta Animal/efectos de los fármacos, Conducta Animal/fisiología, Modelos Animales de Enfermedad, Inmovilización/fisiología, Ketamina/farmacología, Actividad Motora/efectos de los fármacos, Actividad Motora/fisiología, Esquizofrenia/inducido químicamente, Esquizofrenia/fisiopatología, Natación/fisiología